Sandhu Amandeep K, Huang Yancui, Xiao Di, Park Eunyoung, Edirisinghe Indika, Burton-Freeman Britt
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Department of Nutrition, University of California , Davis, California 95616, United States.
J Agric Food Chem. 2016 Jun 22;64(24):4891-9. doi: 10.1021/acs.jafc.6b00805. Epub 2016 Jun 13.
Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m(2)) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.
根据进餐时间，对超重（体重指数：26±2kg/m²）的成年人（n = 14）的血浆草莓花青素进行了特征分析。每次就诊时，受试者摄入三种研究饮料：两种对照饮料和一种草莓饮料。草莓饮料分别在早餐前2小时（BM）、进餐时（WM）或进餐后2小时（AM）饮用，对照饮料在其他时间点饮用。使用三重四极杆液相色谱质谱仪，每小时评估血浆花青素及其代谢共轭物，持续10小时。与进餐时（WM）或进餐后（AM）饮用相比，在进餐前2小时（BM）饮用草莓饮料时，由主要共轭代谢物（天竺葵素葡萄糖醛酸）测定的天竺葵素基花青素的最大浓度（Cmax）、曲线下面积（AUC）和生物利用度更高（p < 0.05）。我们的结果表明，相对于进餐而言，食用草莓的时间会影响花青素的药代动力学变量。
