a Hypertension and Cardiometabolic Syndrome Unit, 1st Department of Cardiology , Medical School, National and Kapodistrian University of Athens, Hippokration Hospital , Athens , Greece.
b Department of Interventional Cardiology , Henry Dunant Hospital , Athens , Greece.
Int J Food Sci Nutr. 2018 Nov;69(7):870-881. doi: 10.1080/09637486.2017.1422700. Epub 2018 Jan 10.
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0.39 m/s, 4.5% and 1.9 mmHg, respectively, for coffee; and by 0.34 m/s, 5.3% and 2.1 mmHg, respectively, for decaffeinated coffee; all p < .05). Caffeine increased PWV, as well as AIx and AP but differences in responses between the two groups were not significant. Both caffeinated and decaffeinated coffee consumption is associated with a more potent effect on arterial stiffness in non-habitual than habitual coffee consumers, whereas caffeine induces comparable changes in both groups.
研究了咖啡对动脉僵硬的急性影响及其对习惯性消费的依赖性，在四个不同的场合，24 名志愿者分别接受了以下四种处理：（a）咖啡浓咖啡，（b）脱咖啡因咖啡浓咖啡，（c）单独咖啡因和（d）安慰剂（热水）。与习惯性饮用者（n=11）相比，非习惯性饮用者（n=13）在饮用咖啡后颈动脉-股动脉脉搏波速度（PWV）、增强指数（AIx）和主动脉压力波形的增强压（AP）增加更为明显，（两组之间最大变化差异分别为 PWV、AIx、AP 反应为 0.39 m/s、4.5%和 1.9 mmHg，咖啡；以及 0.34 m/s、5.3%和 2.1 mmHg，脱咖啡因咖啡；所有 p<.05）。咖啡因增加了 PWV 以及 AIx 和 AP，但两组之间的反应差异不显著。无论是含咖啡因还是脱咖啡因的咖啡消费，在非习惯性消费者中对动脉僵硬的影响都比习惯性消费者更强，而咖啡因在两组中引起的变化相当。
