Sal Ertan, Yenicesu Idil, Celik Nurullah, Pasaoglu Hatice, Celik Bulent, Pasaoglu Ozge Tugce, Kaya Zühre, Kocak Ulker, Camurdan Orhun, Bideci Aysun, Cinaz Peyami
a Department of Pediatric Hematology , Batman State Hospital , Batman , Turkey.
b Pediatric Hematology , Gazi University , Ankara , Turkey.
Hematology. 2018 Sep;23(8):542-548. doi: 10.1080/10245332.2018.1423671. Epub 2018 Jan 10.
Iron deficiency is common in obese children although the underlying mechanism is unclear. The aim of this study was to investigate the associations between iron parameters, leptin, hepcidin and adiponectin levels in obese children.
A total of 237 children, ranging in age from 5 to 18 years, 180 with primary obesity and 57 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, leptin, hepcidin and adiponectin levels were studied.
White blood cell and platelet count, iron-binding capacity, high-sensitive C-reactive protein, leptin and hepcidin values in the obese group were higher than those of the control group (p < 0.001, p = 0.002, p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). However, mean corpuscular volume, adiponectin and transferrin saturation values in the obese group were lower than in the control group (p = 0.026, p = 0.003, and p < 0.001, respectively). No significant differences were found in terms of hemoglobin, serum ferritin, iron and IL-6 levels.
Our study suggests that hepcidin levels do not contribute to the development of iron deficiency anemia in pediatric obese individuals.
缺铁在肥胖儿童中很常见，但其潜在机制尚不清楚。本研究旨在调查肥胖儿童铁参数、瘦素、铁调素和脂联素水平之间的关联。
共纳入237名年龄在5至18岁之间的儿童，其中180名患有原发性肥胖，57名健康儿童和青少年。研究了全血细胞计数、血清铁水平、铁结合能力、铁蛋白水平、瘦素、铁调素和脂联素水平。
肥胖组的白细胞和血小板计数、铁结合能力、高敏C反应蛋白、瘦素和铁调素值高于对照组（分别为p < 0.001、p = 0.002、p < 0.001、p < 0.001、p < 0.001和p < 0.001）。然而，肥胖组的平均红细胞体积、脂联素和转铁蛋白饱和度值低于对照组（分别为p = 0.026、p = 0.003和p < 0.001）。在血红蛋白、血清铁蛋白、铁和白细胞介素-6水平方面未发现显著差异。
我们的研究表明，铁调素水平对小儿肥胖个体缺铁性贫血的发生没有影响。
