党参根中的SIRT1抑制化合物。
SIRT1 inhibitory compounds from the roots of Codonopsis pilosula.
作者信息
Li Xiao-Zhen, Cheng Li-Zhi, Yan Yong-Ming, Liu Bao-Hua, Cheng Yong-Xian
机构信息
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
b School of Traditional Chinese Medicine , Yunnan University of Traditional Chinese Medicine , Kunming 650500 , China.
出版信息
J Asian Nat Prod Res. 2019 Jan;21(1):25-32. doi: 10.1080/10286020.2017.1422491. Epub 2018 Jan 10.
Three new compounds, pilosulinene A (1), pilosulinols A (2), and B (3), along with seven known compounds, were isolated from the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan Province. The structures of new compounds were established by spectroscopic methods. In particular, the presence of an aromatic ring in the structure of 1 makes it intriguing. The inhibitory activity of compounds against SIRT1 was evaluated. The results showed that 8 could inhibit Sirt1 in a dose-dependent manner.
从云南省寻甸县栽培的党参根中分离出三种新化合物，即党参烯A（1）、党参醇A（2）和B（3），以及七种已知化合物。通过光谱方法确定了新化合物的结构。特别值得一提的是，1的结构中存在一个芳香环，这使其颇具吸引力。评估了这些化合物对SIRT1的抑制活性。结果表明，8能够以剂量依赖的方式抑制Sirt1。
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