School of Pharmacy and Chemistry, Dali University, Dali 671000, China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China.
Molecules. 2018 Apr 12;23(4):887. doi: 10.3390/molecules23040887.
Three new polyynes, named choushenpilosulynes A-C (-), were isolated from an 85% aqueous EtOH extract of the roots of cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in and , were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism.
从中国云南省寻甸县种植的中分离得到三种新的聚炔类化合物，命名为 choushenpilosulynes A-C(-)。通过光谱分析和气相色谱（GC）确定了它们的结构，包括 和 中葡萄糖残基的绝对构型。此外，生物评价表明，所有化合物均可抑制 HepG2 细胞中鲨烯单加氧酶（SQLE）基因的表达，提示这些化合物可能参与脂质代谢。
