Dos-Santos Washington Luis Conrado, Sweet Glória Maria Maranhão, Azevêdo Labene Gondim, Tavares Maria Brandão, Soares Maria Fernanda Sanches, Melo Caroline Vilas Boas de, Carneiro Márcia Fernanda Melo, Santos Rilma Ferreira de Souza, Conrado Márcia Cristina, Braga Daniela Teixeira Leal, Bessa Marcia Carvalho, Pinheiro Junior Nathanael de Freitas, Bahiense-Oliveira Marília
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, Salvador - BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública, Salvador - BA, Brazil.
J Bras Nefrol. 2017 Oct-Dec;39(4):376-383. doi: 10.5935/0101-2800.20170069.
A report on the prevalence of glomerular disease diagnosed via renal biopsy in Salvador, BA, Brazil was published in 1973 and showed a predominance of membranoproliferative glomerulonephritis, which was frequently associated with hepatosplenic schistosomiasis.
In this study, we investigate the potential changes in the distribution of glomerular diseases after a period of important epidemiological transition in Brazil.
Pathology reports of all patients subjected to kidney biopsy from 2003 to 2015 in a referral nephrology service were reviewed. Clinical, laboratorial and pathological diagnoses were collected for analysis. Histological slides of the biopsies performed between 2003 and 2006 were reviewed to examine the accuracy of the estimates based on the pathology reports.
Among the biopsies performed during the time period, 1,312 met the inclusion criteria for the study. Focal and segmental glomerulosclerosis was the most prevalent diagnosis, followed by lupus nephritis. However, a trend toward a decrease in the prevalence of focal and segmental glomerulosclerosis was detected (p < 0.05), and an increase in lupus (p < 0.0001) and membranous glomerulonephritis (p < 0.005) was observed.
The data presented herein suggest the occurrence of changes in the distribution of nephrological diseases in Salvador, Brazil. The disease that was most prevalent shifted from membranoproliferative glomerulonephritis to focal and segmental glomerulosclerosis from 1975 to 2006 and from focal and segmental glomerulosclerosis to lupus nephritis from 2006 to 2015.
1973年发表了一篇关于巴西巴伊亚州萨尔瓦多市经肾活检诊断的肾小球疾病患病率的报告，该报告显示膜增生性肾小球肾炎占主导地位，且常与肝脾血吸虫病相关。
在本研究中，我们调查了巴西经历重要流行病学转变一段时间后肾小球疾病分布的潜在变化。
回顾了2003年至2015年在一家转诊肾脏病服务机构接受肾活检的所有患者的病理报告。收集临床、实验室和病理诊断结果进行分析。对2003年至2006年期间进行的活检组织学切片进行复查，以检验基于病理报告的估计准确性。
在该时间段内进行的活检中，1312例符合研究纳入标准。局灶节段性肾小球硬化是最常见的诊断，其次是狼疮性肾炎。然而，检测到局灶节段性肾小球硬化患病率呈下降趋势（p < 0.05），狼疮（p < 0.0001）和膜性肾小球肾炎（p < 0.005）患病率上升。
本文提供的数据表明巴西萨尔瓦多市肾脏病疾病分布发生了变化。从1975年到2006年，最常见的疾病从膜增生性肾小球肾炎转变为局灶节段性肾小球硬化，从2006年到2015年从局灶节段性肾小球硬化转变为狼疮性肾炎。
