Piraciaba Tamires Teixeira, Balda Carlos Alberto, Moura Luiz Antônio Ribeiro de, Pereira Carlos Alberto de Castro, Kirsztajn Gianna Mastroianni
Universidade Federal de São Paulo, Disciplina de Nefrologia, São Paulo - SP, Brazil.
Universidade Federal de São Paulo, Disciplina de Pneumologia, São Paulo - SP, Brazil.
J Bras Nefrol. 2017 Oct-Dec;39(4):473-476. doi: 10.5935/0101-2800.20170084.
Granulomatous interstitial nephritis is a rare condition, in which renal involvement is uncommon. Its etiology is variable, and may be medicinal, infectious or inflammatory origin.
This is a 65-year-old male patient with renal lesions of unknown etiology, associated with hypercalcaemia. During the investigation, cardiac insufficiency with diastolic dysfunction and interstitial lung involvement on chest tomography were evidenced. Renal function (glomerular filtration rate) has partially improved with clinical measures. Renal biopsy was performed, which showed moderate interstitial lesion with tuberculoid granulomas without caseous necrosis.
The objective of the article was to describe a case of NIG and to alert to the importance of its clinical investigation. In this case, renal biopsy, associated with systemic clinical manifestations, contributed to the diagnosis of sarcoidosis.
肉芽肿性间质性肾炎是一种罕见疾病，其中肾脏受累情况并不常见。其病因多样，可能源于药物、感染或炎症。
这是一名65岁男性患者，患有病因不明的肾脏病变，并伴有高钙血症。在检查过程中，证实存在舒张功能障碍导致的心脏功能不全以及胸部断层扫描显示的间质性肺受累。通过临床措施，肾功能（肾小球滤过率）已部分改善。进行了肾活检，结果显示为中度间质性病变，伴有结核样肉芽肿，无干酪样坏死。
本文的目的是描述一例肉芽肿性间质性肾炎病例，并提醒注意其临床检查的重要性。在该病例中，肾活检结合全身临床表现有助于结节病的诊断。
