Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
University of Tampere, Tampere, Finland.
Aliment Pharmacol Ther. 2018 Mar;47(5):563-572. doi: 10.1111/apt.14490. Epub 2018 Jan 11.
The presenting symptoms of coeliac disease are often subtle and the diagnosis is frequently delayed or overlooked. Therefore, especially elderly patients may be denied the benefits conferred by gluten free diet which can be dramatically life-changing.
To review the occurrence, clinical features, diagnosis and management in coeliac patients detected later in life.
To review manuscripts concerned with coeliac disease in the elderly and to derive subgroups of elderly people from publications on the disorder.
Approximately a quarter of all diagnoses are now made at the age of 60 years or more and a fifth at 65 years or over. About 4% are diagnosed at 80 years or above. Around 60% remain undetected, since their symptoms are often subtle: tiredness, indigestion, reduced appetite. Good compliance with gluten free diet, resolution of symptoms and improvement in laboratory indices can be achieved in over 90% of patients.
Coeliac disease not uncommonly presents for the first time in older patients and is an important diagnosis to make.
乳糜泻的临床表现通常较为隐匿，因此其诊断常常被延误或忽视。因此，尤其是老年患者可能无法从无麸质饮食中获益，而这种饮食对他们的生活可能会产生重大的改变。
回顾老年人群中乳糜泻的发病情况、临床特征、诊断和治疗。
对有关老年人乳糜泻的文献进行综述，并从有关该疾病的出版物中提取老年人群亚组。
目前，约四分之一的诊断是在 60 岁或以上做出的，五分之一是在 65 岁或以上做出的。约 4%的诊断出现在 80 岁或以上。约 60%的患者未被发现，因为他们的症状通常较为隐匿，如疲劳、消化不良、食欲不振。超过 90%的患者能够很好地遵循无麸质饮食，症状得到缓解，实验室指标得到改善。
乳糜泻并非罕见地首次出现在老年患者中，是一个需要做出的重要诊断。
