Hankey G L, Holmes G K
Department of Gastroenterology, Derbyshire Royal Infirmary, Derby.
Gut. 1994 Jan;35(1):65-7. doi: 10.1136/gut.35.1.65.
Of 228 patients with adult coeliac disease, 42 (19%) were diagnosed aged 60 years or over. In this series, of 35 patients who did not have dermatitis herpetiformis, 15 had attended family doctors and hospital outpatient departments for an average of 28 years with unexplained symptoms or abnormalities in blood tests but the diagnosis of coeliac disease had been missed. This is unsatisfactory because these patients can both manage and respond to a gluten free diet. Thirty eight patients complied strictly with the diet with resolution of symptoms. Significant improvement in weight, haemoglobin, albumin, calcium, and alkaline phosphatase values after a year on the diet also occurred. Clinicians should be alert to the possibility of coeliac disease in the elderly particularly in patients with non-specific complaints in the presence of unexplained anaemia.
在228例成年乳糜泻患者中,42例(19%)在60岁及以上时被诊断。在本系列研究中,35例无疱疹样皮炎的患者中,15例因不明原因症状或血液检查异常,平均28年来一直在家庭医生和医院门诊就诊,但乳糜泻诊断被漏诊。这令人不满意,因为这些患者能够接受并对无麸质饮食产生反应。38例患者严格遵守饮食规定后症状得到缓解。饮食一年后,体重、血红蛋白、白蛋白、钙和碱性磷酸酶值也有显著改善。临床医生应警惕老年人患乳糜泻的可能性,尤其是在存在不明原因贫血且有非特异性主诉的患者中。