Department of Public Health Sciences, BK21PLUS Program in Embodiment: Health-Society Interaction, Graduate School, Korea University, Seoul, Republic of Korea.
MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Sci Rep. 2018 Jan 11;8(1):458. doi: 10.1038/s41598-017-18856-z.
Previous studies have indicated an association of higher alcohol intake with cardiovascular disease and related traits, but causation has not been definitively established. In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated using an instrumental variable (IV) approach, with both a phenotypic and genotypic instrument for alcohol intake: alcohol flushing and the rs671 genotype (in the alcohol dehydrogenase 2 [ALDH2] gene), respectively. Both alcohol flushing and the rs671 genotype were associated with alcohol intake (difference in alcohol intake with alcohol flushers vs. non-flushers: -9.07 g/day; 95% confidence interval [CI]: -11.12, -7.02; P-value: 8.3 × 10 and with the rs671 GA + AA vs. GG genotype: -7.94 g/day; 95% CI: -10.20, -5.69; P-value: 6.1 × 10). An increase in alcohol intake, as predicted by both the absence of alcohol flushing and the presence of the rs671 GG genotype in the IV analyses, was associated with an increase in blood pressure in men from this Korean population. In conclusion, this study supports a causal effect of alcohol intake on hypertension and indicated that alcohol flushing may be a valid proxy for the ALDH2 rs671 polymorphism, which influences alcohol intake in this Korean population.
先前的研究表明，饮酒量与心血管疾病和相关特征之间存在关联，但因果关系尚未得到明确证实。在这项研究中，我们使用了一种工具变量（IV）方法，对安山-安城队列中 2011 名男性和女性的饮酒与高血压之间的因果关系进行了估计，该方法使用了酒精摄入的表型和基因型工具：酒精潮红和 rs671 基因型（在乙醛脱氢酶 2 [ALDH2] 基因中）。酒精潮红和 rs671 基因型均与饮酒量相关（有酒精潮红者与无酒精潮红者的饮酒量差异：-9.07g/天；95%置信区间 [CI]：-11.12，-7.02；P 值：8.3×10-3）；与 rs671 GA+AA 基因型与 GG 基因型相比：-7.94g/天；95%CI：-10.20，-5.69；P 值：6.1×10-3）。在 IV 分析中，当既没有酒精潮红也没有 rs671 GG 基因型时，预测的饮酒量增加与韩国人群男性的血压升高有关。总之，本研究支持饮酒与高血压之间存在因果关系，并表明酒精潮红可能是影响该韩国人群饮酒量的 ALDH2 rs671 多态性的有效替代指标。
