多态性与韩国人群胃癌风险的关联。
Association between Polymorphism and Gastric Cancer Risk in a Korean Population.
机构信息
Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
出版信息
J Korean Med Sci. 2020 May 4;35(17):e148. doi: 10.3346/jkms.2020.35.e148.
The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 () polymorphism. Therefore, we investigated the relationship between the rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The rs671 genotype was classified as inactive (GG) or active (GA/AA). The risk of gastric cancer was higher in men with the inactive than in those with active (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09-1.39), whereas no significant association was found between genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99-1.02). In men, the association between genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive and high risk of gastric cancer.
酒精与胃癌的关联在东亚人群中比其他人群更强，这可能归因于乙醛脱氢酶 2 （）多态性。因此，我们在韩国人群中调查了 rs671 多态性与胃癌的关系。这项病例对照研究纳入了 3245 名新诊断为胃癌的住院患者和 8732 名人群对照。rs671 基因型分为非活性（GG）或活性（GA/AA）。与活性基因型相比，非活性基因型的男性患胃癌的风险更高（比值比 [OR]，1.25；95%置信区间 [CI]，1.09-1.39），而女性基因型与胃癌之间无显著关联（OR，1.00；95% CI，0.99-1.02）。在男性中，基因型与胃癌的关联在当前饮酒者中更强。我们的研究结果支持了先前报道的非活性基因型与胃癌高风险之间的关联。
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