Department of Epidemiology, Faculty of Social Sciences, University of Tampere, Tampere, Finland.
Scand J Work Environ Health. 2018 May 1;44(3):258-264. doi: 10.5271/sjweh.3705. Epub 2018 Jan 11.
Objective The aim of this case-control study was to assess the effect of night-shift work on the risk of hematological cancers. Methods The study included 39 371 leukemia, 56 713 non-Hodgkin lymphoma, 9322 Hodgkin lymphoma, and 26 188 multiple myeloma cases diagnosed between 1961 and 2005 in Finland, Sweden, and Iceland. Five controls for each case were selected from the Nordic Occupational Cancer Study (NOCCA) cohort, matched by year of birth, sex and country. Night-shift exposure was assessed by using the NOCCA job-exposure matrix (JEM). Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated from conditional logistic regression models. Results Overall, night work was not associated with a risk of hematological cancers. We observed a small but non-significantly increased risk for leukemia (OR 1.07, 95% CI 0.99-1.16), especially for acute myeloid leukemia (OR 1.15, 95% CI 0.97-1.36) among workers exposed to a high level of cumulative night work exposure. Night work exposure was not associated with lymphatic cancers and multiple myeloma. Conclusion This study did not support associations between night-shift work and hematological cancers.
目的 本病例对照研究旨在评估夜班工作对血液系统癌症风险的影响。
方法 该研究纳入了 1961 年至 2005 年间在芬兰、瑞典和冰岛诊断出的 39371 例白血病、56713 例非霍奇金淋巴瘤、9322 例霍奇金淋巴瘤和 26188 例多发性骨髓瘤病例。每例病例均匹配了 5 名来自北欧职业癌症研究（NOCCA）队列的对照，匹配因素包括出生年份、性别和国家。夜班暴露情况通过使用 NOCCA 工作暴露矩阵（JEM）进行评估。使用条件逻辑回归模型计算比值比（OR）和 95%置信区间（95%CI）。
结果 总体而言，夜班工作与血液系统癌症的风险无关。我们观察到，夜班工作暴露水平较高的人群中，白血病（OR 1.07，95%CI 0.99-1.16），尤其是急性髓性白血病（OR 1.15，95%CI 0.97-1.36）的风险略有增加，但无统计学意义。夜班工作暴露与淋巴癌和多发性骨髓瘤无关。
结论 本研究未支持夜班工作与血液系统癌症之间存在关联。
