School of Chemistry and Materials Science, Jiangsu Normal University , Xuzhou 221116, China.
J Org Chem. 2018 Feb 2;83(3):1414-1421. doi: 10.1021/acs.joc.7b02942. Epub 2018 Jan 24.
The first cyclization of para-quinone methide derivatives with alkynes was established by utilizing the [4 + 2] reaction of ortho-hydroxyphenyl-substituted para-quinone methides with ynones or benzyne, which efficiently constructed the scaffolds of chromene and xanthene in high yields (up to 88%). This protocol has not only fulfilled the task of developing cyclization reactions of para-quinone methide derivatives but also provided an efficient method for constructing chromene and xanthene scaffolds.
芳基取代的对醌甲川衍生物与炔烃的首次环化反应是通过利用邻羟基苯基取代的对醌甲川与炔酮或苯炔的[4+2]反应来实现的，该反应以高产率（高达 88%）有效地构建了色烯和呫吨骨架。该方案不仅完成了对醌甲川衍生物的环化反应的开发任务，而且还为构建色烯和呫吨骨架提供了一种有效的方法。
