在真菌代谢产物的迷雾中：2,4,5-三甲氧基苯甘氨酸酸的意外反应。
In the Mists of a Fungal Metabolite: An Unexpected Reaction of 2,4,5-Trimethoxyphenylglyoxylic Acid.
机构信息
Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Otto von Guericke Universität Magdeburg, Chemisches Institut, Universitätsplatz 2, D-39106 Magdeburg, Germany.
出版信息
Molecules. 2020 Apr 23;25(8):1978. doi: 10.3390/molecules25081978.
Abstract
The reactions of phenylglyoxylic acids during the synthesis and biological evaluation of fungal metabolites led to the discovery of hitherto unknown compounds with a -quinone methide (-QM) structure. The formation of these -QMs using C-labelled starting materials revealed a key-step of this reaction being a retro-Friedel-Crafts alkylation.
摘要
苯并恶嗪酸在真菌代谢产物的合成和生物评价过程中的反应导致了具有 - 醌甲叉（-QM）结构的迄今未知化合物的发现。使用 C 标记的起始物料形成这些 -QMs 表明该反应的关键步骤是反 Friedel-Crafts 烷基化反应。
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