a Department of Occupational and Environmental Health Sciences , School of Public Health, Peking University , Beijing , P. R. China.
b Department of Environmental Health Sciences , Jonathan and Karin Fielding School of Public Health, University of California Los Angeles , Los Angeles , CA , USA.
Nanotoxicology. 2018 Mar;12(2):169-184. doi: 10.1080/17435390.2018.1425502. Epub 2018 Jan 11.
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO manufacturing plant in eastern China. Exposure assessment and characterization of TiO particles were performed in a packaging workshop. Physical examination and possible biomarkers for cardiopulmonary effects were examined among 83 exposed workers and 85 controls. In packaging workshop, the total mass concentration of particles was 3.17 mg/m. The mass concentration of nanoparticles was 1.22 mg/m accounting for 39% of the total mass. Lung damage markers (SP-D and pulmonary function), cardiovascular disease markers (VCAM-1, ICAM-1, LDL, and TC), oxidative stress markers (SOD and MDA), and inflammation markers (IL-8, IL-6, IL-1β, TNF-α, and IL-10) were associated with occupational exposure to nano-TiO. Among those markers, SP-D showed a time (dose)-response pattern within exposed workers. The data strongly suggest that nano-TiO could contribute, at least in part, to the cardiopulmonary effects observed in workers. The studied markers and pulmonary function tests may be useful in health surveillance for workers exposed to nanomaterials.
虽然一些毒理学研究报告指出，暴露于二氧化钛纳米颗粒（纳米-TiO）可能会引起不良的心肺效应，但目前从人类收集到的相关数据有限。本研究旨在探讨暴露于纳米-TiO 的工人中的心肺效应，并确定与暴露相关的生物标志物。在中国东部的一家纳米-TiO 制造工厂进行了一项横断面研究。在包装车间进行暴露评估和 TiO 颗粒特征描述。对 83 名暴露工人和 85 名对照进行了心肺效应的体检和可能的生物标志物检查。在包装车间，颗粒的总质量浓度为 3.17mg/m。纳米颗粒的质量浓度为 1.22mg/m，占总质量的 39%。肺损伤标志物（SP-D 和肺功能）、心血管疾病标志物（VCAM-1、ICAM-1、LDL 和 TC）、氧化应激标志物（SOD 和 MDA）和炎症标志物（IL-8、IL-6、IL-1β、TNF-α 和 IL-10）与职业暴露于纳米-TiO 有关。在这些标志物中，SP-D 在暴露工人中表现出时间（剂量）-反应模式。数据强烈表明，纳米-TiO 至少部分导致了工人中观察到的心肺效应。研究的标志物和肺功能测试可能对暴露于纳米材料的工人的健康监测有用。
