Ichihara Sahoko
Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, 329-0498Japan.
J Occup Health. 2025 Jan 4;67(1). doi: 10.1093/joccuh/uiae080.
With the explosive development of nanotechnology, engineered nanomaterials are currently being used in various industries, including food and medicine. Concern about the health effects of nanomaterials has been raised, and available research indicates that the relative surface area of nanomaterials seems to correlate with the severity of their toxicity. With regard to engineered nanomaterials, the scope of their acute and chronic toxicities and their mechanisms are not fully understood. Studies suggest that exposure to certain nanomaterials can generate reactive oxidant species and enhance permeability of the phagolysosomal membrane, which leads to inflammasome activation, causing oxidative stress and inflammation. Since the latter 2 are implicated in the development of cardiovascular diseases, such as hypertension and atherosclerosis, it can be presumed that exposure to engineered nanomaterials could significantly impact cardiovascular function. In this review, I raise issues that should be considered in the assessment of the effects of engineered nanomaterials on cardiovascular function, and evaluate their cardiovascular toxicity as described in various in vitro and/or in vivo toxicological studies and industrial investigations.
随着纳米技术的迅猛发展，工程纳米材料目前正应用于包括食品和医药在内的各个行业。人们已开始关注纳米材料对健康的影响，现有研究表明，纳米材料的相对表面积似乎与其毒性严重程度相关。关于工程纳米材料，其急性和慢性毒性范围及其作用机制尚未完全明确。研究表明，接触某些纳米材料可产生活性氧化物质并增强吞噬溶酶体膜的通透性，进而导致炎性小体激活，引发氧化应激和炎症。鉴于后两者与高血压和动脉粥样硬化等心血管疾病的发生有关，可以推测接触工程纳米材料可能会对心血管功能产生重大影响。在这篇综述中，我提出了在评估工程纳米材料对心血管功能影响时应考虑的问题，并根据各种体外和/或体内毒理学研究及行业调查中所描述的情况，对它们的心血管毒性进行了评估。
