van de Laar Thijs J, Van Gaever Véronique A, Swieten Peter van, Muylaert An, Compernolle Veerle, Zaaijer Hans L
Department op Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands.
Blood Service, Belgian Red Cross-Flanders, Mechelen, Belgium.
Virology. 2018 Feb;515:243-249. doi: 10.1016/j.virol.2017.12.011. Epub 2018 Jan 8.
During 2006-2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior.
2006年至2016年期间，在荷兰和佛兰德的近400名献血者中检测到乙肝病毒（HBV）。将献血者退出访谈中披露的献血者人口统计学信息和自我报告的风险因素与献血者和参考序列的HBV系统发育进行了比较。慢性HBV感染的首次献血者通常是移民（67%），感染了基因高度多样的A（32%）、B（8%）、C（6%）、D（53%）以及E至H（1%）基因型毒株。每种亚型都与献血者种族密切相关。相比之下，62例急性/近期HBV感染中有57例（93%）发生在本地献血者中，其中67%感染了一种广泛传播的特定流行HBV-A2谱系。HBV分型确定了三种不同的流行病学特征：通过移民输入慢性HBV感染、西欧境内非流行HBV-A2毒株的长期传播，以及最有可能由性风险行为推动的一种流行HBV-A2毒株的活跃传播。
