关联中国环境细颗粒物暴露与人类生育率。
Associating ambient exposure to fine particles and human fertility rates in China.
机构信息
Department of Earth System Science, Tsinghua University, Beijing, China.
Department of Earth System Science, Tsinghua University, Beijing, China.
出版信息
Environ Pollut. 2018 Apr;235:497-504. doi: 10.1016/j.envpol.2018.01.009. Epub 2018 Jan 8.
BACKGROUND
Adverse effects of ambient fine particles (PM) on sperm quality and oocyte fertilization have been identified by previous research. However, insufficient human studies tested associations between PM and decreased fertility rates.
METHODS
We associated long-term exposure to PM and county-level fertility rates reported by 2010 census across China. Exposure assessments were based on PM maps (2009-2010) with a spatial resolution of 0.1° derived from satellite remote sensing data from another published study. We used a Poisson regression to examine the relationship between PM and fertility rates with adjustment of potential confounders including county-level socioeconomic factors (e.g. sex ratio) and a spatially smoothed trend.
RESULTS
We found that fertility rates were significantly decreased by 2.0% (95% confidence interval: 1.8%, 2.1%) per 10 μg/m increment of PM. We also found a geographical variation of the associations.
CONCLUSIONS
The study add to epidemiological evidences on adverse effects of PM on fertility rates.
背景
先前的研究已经确定了环境细颗粒物（PM）对精子质量和卵子受精的不良影响。然而，人类研究的证据不足，无法检验 PM 与降低生育率之间的关系。
方法
我们将中国 2010 年人口普查报告的长期 PM 暴露和县级生育率联系起来。暴露评估基于 PM 地图（2009-2010 年），空间分辨率为 0.1°，来自另一项已发表研究的卫星遥感数据。我们使用泊松回归检验 PM 与生育率之间的关系，并调整了潜在的混杂因素，包括县级社会经济因素（如性别比例）和空间平滑趋势。
结果
我们发现，每增加 10μg/m³的 PM，生育率就会显著下降 2.0%（95%置信区间：1.8%，2.1%）。我们还发现了关联的地理变化。
结论
该研究增加了 PM 对生育率的不良影响的流行病学证据。
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