Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China; Department of Environmental and Occupational Health, Public Health Ontario, Toronto, ON, Canada; Primary Care and Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China.
Sci Total Environ. 2019 Nov 15;691:868-873. doi: 10.1016/j.scitotenv.2019.07.179. Epub 2019 Jul 12.
The health effects of particulate matter (PM) air pollution on glucose metabolism have been rarely examined in children and adolescents.
We aimed to investigate the associations between long-term PM exposure and blood glucose and prevalence of impaired fasting glucose in a large population of Chinese children and adolescents.
In 2013, a total of 11,814 children and adolescents aged 7 to 18 years were recruited from seven provinces/municipalities in China. Fasting blood sample was taken for the measurement of blood glucose. Satellite-based spatial-temporal models were used to estimate exposure to ambient submicrometer particles (PM), fine particles (PM) and thoracic particles (PM). Cross-sectional analyses were performed using mixed-effects multivariable linear and logistic regression models.
After adjustment for a range of covariates, every 10 μg/m increment in PM, PM and PM concentrations was associated with 0.160 [95% confidence interval (CI): 0.039, 0.280], 0.150 (95% CI: 0.044, 0.256) and 0.079 (95% CI: -0.009, 0.167) mmol/L higher blood glucose levels, respectively. PM exposure was also associated with higher prevalence of impaired fasting glucose, but the associations did not reach statistical significance [odds ratio per 10 μg/m increment in PM, PM and PM: 1.30 (95% CI: 0.86,1.96), 1.20 (95% CI: 0.85,1.69) and 1.08 (95% CI: 0.83,1.41)].
We found that long-term exposure to PM air pollution was associated with increased levels of blood glucose in children and adolescents. The associations were more evident for PM and PM.
颗粒物（PM）空气污染对葡萄糖代谢的健康影响在儿童和青少年中很少被研究。
我们旨在研究在中国一个大型儿童和青少年人群中，长期 PM 暴露与血糖及空腹血糖受损的患病率之间的关系。
2013 年，在中国七个省/直辖市共招募了 11814 名 7 至 18 岁的儿童和青少年。采集空腹血样以测量血糖。利用基于卫星的时空模型来估计环境亚微米颗粒物（PM）、细颗粒物（PM）和胸颗粒物（PM）的暴露情况。采用混合效应多变量线性和逻辑回归模型进行横断面分析。
在校正了一系列协变量后，PM、PM 和 PM 浓度每增加 10μg/m，血糖水平分别升高 0.160（95%置信区间：0.039，0.280）、0.150（95%置信区间：0.044，0.256）和 0.079（95%置信区间：-0.009，0.167）mmol/L。PM 暴露也与空腹血糖受损的患病率升高相关，但关联未达到统计学意义[PM、PM 和 PM 每增加 10μg/m 的比值比：1.30（95%置信区间：0.86，1.96）、1.20（95%置信区间：0.85，1.69）和 1.08（95%置信区间：0.83，1.41）]。
我们发现，长期暴露于 PM 空气污染与儿童和青少年的血糖水平升高有关。PM 和 PM 的关联更为明显。
