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第二产程时长增加时的孕产妇及围产期结局

Maternal and perinatal outcomes with increasing duration of the second stage of labor.

作者信息

Allen Victoria M, Baskett Thomas F, O'Connell Colleen M, McKeen Dolores, Allen Alexander C

机构信息

From the Department of Obstetrics and Gynaecology, the Perinatal Epidemiology Research Unit, and the Departments of Anaesthesia and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Obstet Gynecol. 2009 Jun;113(6):1248-1258. doi: 10.1097/AOG.0b013e3181a722d6.

Abstract

OBJECTIVE

To estimate maternal and perinatal outcomes among women with increasing duration of the second stage of labor.

METHODS

A population-based cohort study was conducted among women with low-risk, singleton, vertex, nonanomalous deliveries at or after 37 weeks of gestation between 1988 and 2006. Individual maternal (hemorrhagic, infectious, and traumatic), perinatal (birth depression, infectious, and traumatic), and composite outcomes were evaluated with increasing duration of the second stage. Logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals for all outcomes and to account for confounding variables, including maternal age, prelabor rupture of membranes, augmentation of labor, antibiotics in labor, regional analgesia, gestational age, birth weight, and year of birth. Effect modification caused by method of delivery was considered.

RESULTS

From a population of 193,823 women, 121,517 women met inclusion and exclusion criteria, of whom 63,404 (52%) were nulliparous. There was an increase in risk of maternal obstetric trauma, postpartum hemorrhage, puerperal febrile morbidity and composite maternal morbidity, and low 5-minute Apgar score, birth depression, admission to the neonatal intensive care unit, and composite perinatal morbidity among both nulliparous women and multiparous women, with increasing duration of the second stage of labor. Method of delivery only modified the effect of duration of second stage among nulliparous women.

CONCLUSION

Risks of both maternal and perinatal adverse outcomes rise with increased duration of the second stage, particularly for duration longer than 3 hours in nulliparous women and longer than 2 hours in multiparous women.

LEVEL OF EVIDENCE

II.

摘要

目的

评估第二产程时间延长的产妇及其围产儿结局。

方法

对1988年至2006年期间妊娠37周及以后进行低风险、单胎、头先露、无畸形分娩的妇女进行基于人群的队列研究。随着第二产程时间的增加,评估个体产妇结局(出血、感染和创伤性)、围产儿结局(出生时窒息、感染和创伤性)以及综合结局。采用逻辑回归估计所有结局的调整比值比和95%置信区间,并考虑混杂变量,包括产妇年龄、临产前胎膜破裂、引产、产时使用抗生素、区域镇痛、孕周、出生体重和出生年份。考虑分娩方式引起的效应修饰。

结果

在193,823名妇女中,121,517名妇女符合纳入和排除标准,其中63,404名(52%)为初产妇。随着第二产程时间的增加,初产妇和经产妇的产妇产科创伤、产后出血、产褥期发热发病率和综合产妇发病率以及5分钟Apgar评分低、出生时窒息、入住新生儿重症监护病房和综合围产儿发病率的风险均增加。分娩方式仅改变了初产妇第二产程时间的效应。

结论

第二产程时间延长会增加产妇和围产儿不良结局的风险,尤其是初产妇第二产程时间超过3小时、经产妇超过2小时。

证据级别

II级。

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