药物性肝损伤的分子研究。
Molecular Research on Drug Induced Liver Injury.
机构信息
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, Frankfurt am Main, D-63450 Hanau, Germany.
Pharmacovigilance Consultancy, 75020 Paris, France.
出版信息
Int J Mol Sci. 2018 Jan 11;19(1):216. doi: 10.3390/ijms19010216.
Abstract
Drugs may cause liver injury in a few susceptible individuals, but the molecular events that lead to this idiosyncratic, largely dose-independent and non-predictable drug-induced liver injury (DILI) are mostly unknown, since animal models to explore the pathogenetic mechanisms of human idiosyncratic DILI are not yet reliable.[...].
摘要
药物可能会导致少数易感个体肝损伤，但导致这种体质特异、很大程度上与剂量无关且不可预测的药物性肝损伤（DILI）的分子事件在很大程度上仍是未知的，因为用于探索人类体质特异 DILI 发病机制的动物模型尚不可靠。[...].
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