青年男性性功能障碍：与勃起功能障碍相关的膳食成分概述。

Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction.

机构信息

Laboratory of Hygiene, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; 1st Department of Urology, "G. Gennimatas" General Hospital of Thessaloniki, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Laboratory of Hygiene, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Nutrition and Dietetics, Alexander Technological Educational Institute, Thessaloniki, Greece.

出版信息

J Sex Med. 2018 Feb;15(2):176-182. doi: 10.1016/j.jsxm.2017.12.008. Epub 2018 Jan 8.

DOI:10.1016/j.jsxm.2017.12.008

PMID:29325831

Abstract

BACKGROUND

Sexual dysfunction is relatively common in young men, presenting in diverse manifestations, including erectile dysfunction (ED), for which dietary modifications, including increased intake of dietary antioxidants, have been suggested as promising and cost-efficient approaches.

AIM

To assess the consumption of selected dietary antioxidants, in particular flavonoids, in relation to ED symptoms in young men.

METHODS

Men 18 to 40 years old were invited to complete an anonymous web-based questionnaire for this case-control study. ED was diagnosed with the International Index of Erectile Function (IIEF) and flavonoid intake was recorded using food-frequency questionnaires, with an emphasis on flavonoid-rich foods such as coffee, fruits, etc. Participants without ED (IIEF score ≥ 26; n = 264) formed the control group and those with ED (IIEF score < 26; n = 86) formed the case group.

OUTCOMES

Dietary flavonoid intake.

RESULTS

Men with ED reported a lower median monthly intake of total flavonoids (-2.18 g, 95% CI = -3.15 to -1.21, P < .001) and all flavonoid subclasses (P < .001) compared with controls. Adjustment of intake for age and body mass index showed that consumption of flavonoids 50 mg/day lowered the risk for ED by 32% (odds ratio = 0.68, 95% CI = 0.55-0.85, P < .001). Of all recorded flavonoids, flavones appeared to contribute the most to healthy erectile function. Controls reported a greater consumption of vegetables and fruits, a lower intake of dairy and alcoholic beverages, and a less intense smoking habit compared with cases (P < .001).

CLINICAL IMPLICATIONS

Increased intake of fruits, vegetables, and flavonoids decreases the risk of ED in young men.

STRENGTH AND LIMITATIONS

The strength of this study stems from the innovative hypothesis, the young age of participants, and the suggested therapeutic effects of cheap dietary components against ED. Limitations include the relatively small sample and cross-sectional design.

CONCLUSION

Low flavonoid-in particular flavone-intake is associated with ED in young adult men. Mykoniatis I, Grammatikopoulou MG, Bouras E, et al. Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction. J Sex Med 2018;15:176-182.

摘要

背景

性功能障碍在年轻男性中较为常见，表现形式多样，包括勃起功能障碍（ED）。为此，人们提出了通过饮食调整来改善 ED，包括增加膳食抗氧化剂的摄入，这是一种有前景且具有成本效益的方法。

目的

评估年轻男性的 ED 症状与特定膳食抗氧化剂（特别是类黄酮）的摄入之间的关系。

方法

我们邀请了 18 至 40 岁的男性参加这项病例对照研究的在线匿名问卷调查。使用国际勃起功能指数（IIEF）诊断 ED，通过食物频率问卷记录类黄酮的摄入量，重点关注富含类黄酮的食物，如咖啡、水果等。没有 ED（IIEF 评分≥26；n=264）的男性组成对照组，而有 ED（IIEF 评分<26；n=86）的男性组成病例组。

结果

ED 患者报告的每月总类黄酮摄入量中位数较低（-2.18g，95%CI=-3.15 至-1.21，P<.001）和所有类黄酮亚类的摄入量均较低（P<.001）。对年龄和体重指数进行摄入量调整后发现，每天摄入 50 毫克类黄酮可使 ED 风险降低 32%（比值比=0.68，95%CI=0.55-0.85，P<.001）。在所有记录的类黄酮中，类黄酮似乎对健康的勃起功能贡献最大。与病例组相比，对照组报告摄入更多的蔬菜和水果、更少的乳制品和酒精饮料、以及较少的吸烟量（P<.001）。

临床意义

增加水果、蔬菜和类黄酮的摄入可降低年轻男性发生 ED 的风险。

优势和局限性

本研究的优势在于创新性的假设、参与者的年轻年龄以及廉价饮食成分对 ED 可能具有治疗作用的推测。局限性包括样本量较小和横断面设计。

结论

低类黄酮（特别是类黄酮）摄入与年轻成年男性的 ED 相关。Mykoniatis I, Grammatikopoulou MG, Bouras E, et al. Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction. J Sex Med 2018;15:176-182.