Yang Bin, Wei Chao, Zhang Yu-Cong, Ma De-Lin, Bai Jian, Liu Zhuo, Liu Xia-Ming, Liu Ji-Hong, Yuan Xiao-Yi, Yao Wei-Min
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Asian J Androl. 2025 Mar 1;27(2):239-244. doi: 10.4103/aja202485. Epub 2024 Oct 29.
Erectile dysfunction (ED) is prevalent among men, but its relationship with dietary habits is uncertain. The aim of our study was to assess whether dietary patterns enhance erectile function by reviewing the literature published before August 1, 2022, via PubMed, Web of Science, and EMBASE databases. The data compiled included author details; publication dates, countries, treatments, patient numbers, ages, follow-ups, and clinical trial outcomes, such as ED cases, odds ratios (ORs), confidence intervals (CIs), and International Index of Erectile Function-5 (IIEF-5) scores with means and standard deviations. An analysis of 14 studies with 27 389 participants revealed that plant-based diets (OR = 0.71, 95% CI: 0.66-0.75; P < 0.00001), low-fat diets (OR = 0.27, 95% CI: 0.13-0.53; P = 0.0002), and alternative diets such as intermittent fasting and organic diets (OR = 0.54, 95% CI: 0.36-0.80; P = 0.002) significantly reduced ED risk. High-protein low-fat diets (hazard ratio [HR] = 1.38, 95% CI: 1.12-1.64; P < 0.00001) and high-carb low-fat diets (HR = 0.79, 95% CI: 0.55-1.04; P < 0.00001) improved IIEF-5 scores. Combined diet and exercise interventions decreased the likelihood of ED (OR = 0.49, 95% CI: 0.28-0.85; P = 0.01) and increased the IIEF-5 score (OR = 3.40, 95% CI: 1.69-5.11; P < 0.0001). Diets abundant in fruits and vegetables (OR = 0.97, 95% CI: 0.96-0.98; P < 0.00001) and nuts (OR = 0.54, 95% CI: 0.37-0.80; P = 0.002) were also correlated with lower ED risk. Our meta-analysis underscores a strong dietary-ED association, suggesting that low-fat/Mediterranean diets rich in produce and nuts could benefit ED management.
勃起功能障碍（ED）在男性中很普遍，但其与饮食习惯的关系尚不确定。我们研究的目的是通过检索2022年8月1日前发表在PubMed、科学网和EMBASE数据库上的文献，评估饮食模式是否能增强勃起功能。汇总的数据包括作者详情、发表日期、国家、治疗方法、患者数量、年龄、随访情况以及临床试验结果，如ED病例、比值比（OR）、置信区间（CI）和国际勃起功能指数-5（IIEF-5）评分及均值和标准差。对14项研究中的27389名参与者进行的分析显示，植物性饮食（OR = 0.71，95%CI：0.66 - 0.75；P < 0.00001）、低脂饮食（OR = 0.27，95%CI：0.13 - 0.53；P = 0.0002）以及间歇性禁食和有机饮食等替代饮食（OR = 0.54，95%CI：0.36 - 0.80；P = 0.002）可显著降低ED风险。高蛋白低脂饮食（风险比[HR] = 1.38，95%CI：1.12 - 1.64；P < 0.00001）和高碳水化合物低脂饮食（HR = 0.79，95%CI：0.55 - 1.04；P < 0.00001）可提高IIEF-5评分。饮食与运动相结合的干预措施降低了ED的发生可能性（OR = 0.49，95%CI：0.28 - 0.85；P = 0.01）并提高了IIEF-5评分（OR = 3.40，95%CI：1.69 - 5.11；P < 0.0001）。富含水果和蔬菜的饮食（OR = 0.97，95%CI：0.96 - 0.98；P < 0.00001）和坚果（OR = 0.54，95%CI：0.37 - 0.80；P = 0.002）也与较低的ED风险相关。我们的荟萃分析强调了饮食与ED之间的紧密关联，表明富含农产品和坚果的低脂/地中海饮食可能有助于ED的管理。
