一项加拿大全基因组关联研究及荟萃分析证实，人类白细胞抗原（HLA）是花生过敏的一个风险因素，与哮喘无关。 - Suppr

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.

作者信息

Asai Yuka, Eslami Aida, van Ginkel C Dorien, Akhabir Loubna, Wan Ming, Yin David, Ellis George, Ben-Shoshan Moshe, Marenholz Ingo, Martino David, Ferreira Manuel A, Allen Katrina, Mazer Bruce, de Groot Hans, de Jong Nicolette W, Gerth van Wijk Roy, Dubois Anthony E J, Grosche Sarah, Ashley Sarah, Rüschendorf Franz, Kalb Birgit, Beyer Kirsten, Nöthen Markus M, Lee Young-Ae, Chin Rick, Cheuk Stephen, Hoffman Joshua, Jorgensen Eric, Witte John S, Melles Ronald B, Hong Xiumei, Wang Xiaobin, Hui Jennie, Musk Arthur W Bill, Hunter Michael, James Alan L, Koppelman Gerard H, Sandford Andrew J, Clarke Ann E, Daley Denise

机构信息

Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada, and the Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

J Allergy Clin Immunol. 2018 Apr;141(4):1513-1516. doi: 10.1016/j.jaci.2017.10.047. Epub 2018 Jan 8.

DOI:10.1016/j.jaci.2017.10.047

PMID:29325868

Abstract

摘要

相似文献

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.一项加拿大全基因组关联研究及荟萃分析证实，人类白细胞抗原（HLA）是花生过敏的一个风险因素，与哮喘无关。

J Allergy Clin Immunol. 2018 Apr;141(4):1513-1516. doi: 10.1016/j.jaci.2017.10.047. Epub 2018 Jan 8.

Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.花生过敏患者及其可耐受花生的兄弟姐妹之间存在花生特异性 IgG 的巨大差异，且这种差异与 HLA Ⅱ类无关。

Clin Immunol. 2010 Dec;137(3):366-73. doi: 10.1016/j.clim.2010.08.009. Epub 2010 Sep 17.

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.全基因组关联研究确定了美国儿童花生过敏特异性位点及表观遗传介导的证据。

Nat Commun. 2015 Feb 24;6:6304. doi: 10.1038/ncomms7304.

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1.花生过敏的全基因组关联研究再现了与HLA-DRB1中氨基酸多态性的关联。

Clin Exp Allergy. 2017 Feb;47(2):217-223. doi: 10.1111/cea.12863. Epub 2017 Jan 11.

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy.全基因组关联研究和多人群荟萃分析鉴定了花生过敏的新易感基因位点，并确定 C11orf30/EMSY 为食物过敏的遗传危险因素。

J Allergy Clin Immunol. 2018 Mar;141(3):991-1001. doi: 10.1016/j.jaci.2017.09.015. Epub 2017 Oct 10.

The evolving story of human leukocyte antigen and the immunogenetics of peanut allergy.人类白细胞抗原的演变历程与花生过敏的免疫遗传学

Ann Allergy Asthma Immunol. 2015 Dec;115(6):471-6. doi: 10.1016/j.anai.2015.10.008. Epub 2015 Oct 27.

Utility of Ara h 2 sIgE levels to predict peanut allergy in Canadian children.Ara h 2特异性IgE水平对预测加拿大儿童花生过敏的效用。

J Allergy Clin Immunol Pract. 2015 Nov-Dec;3(6):968-9. doi: 10.1016/j.jaip.2015.04.001. Epub 2015 May 1.

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status.尽管花生过敏诊断标准或哮喘状态存在差异，但丝聚合蛋白基因突变与花生过敏之间的关联依然存在。

J Allergy Clin Immunol. 2013 Jul;132(1):239-42. doi: 10.1016/j.jaci.2013.03.043. Epub 2013 May 16.

Peanut allergy in Mexican children: what is the effect of age at first consumption?墨西哥儿童的花生过敏：首次食用时的年龄有何影响？

Iran J Allergy Asthma Immunol. 2016 Feb;15(1):53-61.

The predictive relationship between peanut- and Ara h 2-specific serum IgE concentrations and peanut allergy.花生特异性和Ara h 2特异性血清IgE浓度与花生过敏之间的预测关系。

J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):131-2.e1. doi: 10.1016/j.jaip.2014.10.014. Epub 2014 Dec 2.

引用本文的文献

HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals.非西班牙裔黑人个体中与花生过敏和过敏反应相关的HLA变异

J Allergy Clin Immunol Glob. 2025 Apr 22;4(3):100485. doi: 10.1016/j.jacig.2025.100485. eCollection 2025 Aug.

Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.食物过敏的遗传学与表观遗传学：全基因组关联研究综述

Allergy. 2025 Jan;80(1):106-131. doi: 10.1111/all.16429. Epub 2024 Dec 19.

In Silico Identification of Peanut Peptides Suitable for Allergy Immunotherapy in HLA-DRB1*03:01-Restricted Patients.在计算机模拟中鉴定适合 HLA-DRB1*03:01 限制性患者进行过敏免疫治疗的花生肽

Pharmaceuticals (Basel). 2024 Aug 21;17(8):1097. doi: 10.3390/ph17081097.

A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.Themis 突变导致 CC027 小鼠口服花生挑战后过敏严重。

J Allergy Clin Immunol. 2024 Aug;154(2):387-397. doi: 10.1016/j.jaci.2024.03.027. Epub 2024 Apr 24.

A Review of the Epigenetic Clock: Emerging Biomarkers for Asthma and Allergic Disease.《表观遗传时钟述评：哮喘和过敏性疾病的新兴生物标志物》。

Genes (Basel). 2023 Aug 29;14(9):1724. doi: 10.3390/genes14091724.

A mutation in contributes to peanut-induced oral anaphylaxis in CC027 mice.某一基因的突变导致CC027小鼠出现花生诱导的口腔过敏反应。

bioRxiv. 2023 Sep 13:2023.09.13.557467. doi: 10.1101/2023.09.13.557467.

Multi-omics profiling approach in food allergy.食物过敏中的多组学分析方法

World Allergy Organ J. 2023 May 15;16(5):100777. doi: 10.1016/j.waojou.2023.100777. eCollection 2023 May.

Peanut Allergenicity: An Insight into Its Mitigation Using Thermomechanical Processing.花生致敏性：对采用热机械加工减轻致敏性的见解。

Foods. 2023 Mar 15;12(6):1253. doi: 10.3390/foods12061253.

Genetics of Food Allergy.食物过敏的遗传学。

Immunol Allergy Clin North Am. 2021 May;41(2):301-319. doi: 10.1016/j.iac.2021.01.010. Epub 2021 Mar 26.

IgE-Mediated Peanut Allergy: Current and Novel Predictive Biomarkers for Clinical Phenotypes Using Multi-Omics Approaches.免疫球蛋白 E 介导的花生过敏：使用多组学方法的临床表型的当前和新型预测生物标志物。

Front Immunol. 2021 Jan 28;11:594350. doi: 10.3389/fimmu.2020.594350. eCollection 2020.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献