浸润型巨噬细胞在早期被广泛激活，以支持急性骨骼肌损伤修复。
Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair.
机构信息
Department of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Department of Human Oncology, Memorial Sloan Kattering Cancer Center, New York, NY 10065, United States.
出版信息
J Neuroimmunol. 2018 Apr 15;317:55-66. doi: 10.1016/j.jneuroim.2018.01.004. Epub 2018 Jan 4.
Abstract
Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C at day 1 after BaCl injection, while many were Ly6C at day 3. Ly6C macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C and Ly6C macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.
摘要
急性骨骼肌损伤修复需要一个以巨噬细胞浸润为主的适当炎症反应。我们通过分析 M1/M2 特征基因的表达来研究浸润巨噬细胞的激活。BaCl 注射后第 1 天，大部分肌内巨噬细胞为 Ly6C，而第 3 天很多为 Ly6C。第 1 天的 Ly6C 巨噬细胞高水平表达 M1 和 M2 基因，而第 3 天的 Ly6C 和 Ly6C 巨噬细胞表达许多 M1/M2 基因的水平相似。在早期阶段，浸润巨噬细胞广泛激活而不是极化，以支持急性骨骼肌损伤修复。
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