Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
PLoS One. 2012;7(10):e46974. doi: 10.1371/journal.pone.0046974. Epub 2012 Oct 4.
Previously, CYP1A1 Ile462Val polymorphism has been indicated to be a risk factor for several malignancies. Increasing reports have focused on the association of CYP1A1 Ile462Val polymorphisms with susceptibility to acute leukemia and have generated controversial results. The goal of the present study was to derive a more precise estimation of the relationship.
Relevant literature has been rigorously searched and screened. Eligible studies were identified for the period up to Apr 2012. Meta-analyses evaluating the association of CYP1A1 Ile462Val variation with acute leukemia were carried out. Subgroup analyses on ethnicity, clinical types and source of controls were further performed.
A total of thirteen publications including fourteen case-control studies with 2164 cases and 4160 controls were selected for analysis. The overall data indicated a significant association of CYP1A1 Ile462Val polymorphism with acute leukemia risk (Val/Val vs Ile/Ile OR = 1.49; 95% CI = 1.11-1.98; dominant model: OR = 1.26; 95% CI = 1.05-1.51; recessive model: OR = 1.38; 95% CI = 1.04-1.83). In subgroup analysis on ethnicity, increased risk was shown among mixed ethnicities (Val/Val vs Ile/Ile: OR = 2.36; 95% CI = 1.46-3.82; dominant model: OR = 1.37; 95% CI = 1.01-1.86; recessive model: OR = 2.20; 95% CI = 1.37-3.53) but not Asians or Caucasians. In subgroup analysis on clinical types, increased risk was observed in the acute lymphocytic leukemia (ALL) subgroup (Val/Val vs Ile/Ile: OR = 2.06; 95% CI = 1.42-3.01; recessive model: OR = 1.91; 95% CI = 1.32-2.76) but not in the acute myeloid leukemia (AML) subgroup.
The results of the present study suggest that CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia. Subgroup analyses suggest that homozygous Val/Val alleles might modify the susceptibility to ALL.
先前的研究表明，CYP1A1 Ile462Val 多态性是多种恶性肿瘤的危险因素。越来越多的报告集中在 CYP1A1 Ile462Val 多态性与急性白血病易感性的相关性上，并得出了有争议的结果。本研究的目的是更准确地评估这种关系。
严格搜索和筛选相关文献。确定截至 2012 年 4 月的相关研究。对评估 CYP1A1 Ile462Val 变异与急性白血病关系的荟萃分析进行了评估。进一步进行了基于种族、临床类型和对照来源的亚组分析。
共纳入 13 项研究，包括 14 项病例对照研究，共 2164 例病例和 4160 例对照。总体数据表明，CYP1A1 Ile462Val 多态性与急性白血病风险显著相关（Val/Val 与 Ile/Ile，OR=1.49；95%CI=1.11-1.98；显性模型：OR=1.26；95%CI=1.05-1.51；隐性模型：OR=1.38；95%CI=1.04-1.83）。在种族亚组分析中，混合种族中风险增加（Val/Val 与 Ile/Ile：OR=2.36；95%CI=1.46-3.82；显性模型：OR=1.37；95%CI=1.01-1.86；隐性模型：OR=2.20；95%CI=1.37-3.53），而非亚洲人和高加索人。在临床类型亚组分析中，在急性淋巴细胞白血病（ALL）亚组中观察到风险增加（Val/Val 与 Ile/Ile：OR=2.06；95%CI=1.42-3.01；隐性模型：OR=1.91；95%CI=1.32-2.76），而非急性髓系白血病（AML）亚组。
本研究结果表明，CYP1A1 Ile462Val 多态性可能是急性白血病的低外显率危险因素。亚组分析表明，纯合子 Val/Val 等位基因可能会改变 ALL 的易感性。
