Nourian Alireza, Soleimanzadeh Ali, Shalizar Jalali Ali, Najafi Gholamreza
Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Vet Res Forum. 2017;8(4):341-345. Epub 2017 Dec 15.
Bisphenol-S (BPS) is a new bisphenol-A substitute widely used in many plastic products. Bisphenol-A as a main member of bisphenol family has been known as an endocrine system disrupter chemical compound. Like other members of bisphenol family, there is public health concern about the toxic effects of BPS on reproductive system, thus, we examined BPS effects on fertilization (IVF) potential and oxidative stress status in a murine model. Adult female mice (n = 70) were randomly divided into control and BPS-treated groups. Bisphenol-S was administered at doses of 0, 1, 5, 10, 50 and 100 µg kg body weight per day intraperitoneally for 21 consecutive days. Twenty-Four hr after the last treatment, five mice in each group were super-ovulated and the oocytes were harvested for IVF. All ovaries were collected and used for biochemical factors analyses. Bisphenol-S exposure at doses more than 10 µg kg induced developmental arrest of pre-implantation embryos. Further, lipid peroxidation measurement in ovaries indicated that all doses of BPS cause oxidative stress in female mice. In conclusion, BPS administration even in low doses can result in female reproductive toxicities and oxidative stress in mice.
双酚S（BPS）是一种新型双酚A替代品，广泛应用于许多塑料制品中。双酚A作为双酚家族的主要成员，已被认为是一种内分泌系统干扰化合物。与双酚家族的其他成员一样，BPS对生殖系统的毒性作用引起了公众对健康的关注，因此，我们在小鼠模型中研究了BPS对受精（体外受精）潜力和氧化应激状态的影响。成年雌性小鼠（n = 70）被随机分为对照组和BPS处理组。双酚S以每天0、1、5、10、50和100 µg/kg体重的剂量腹腔注射，连续注射21天。在最后一次处理后24小时，每组五只小鼠进行超排卵，并收集卵母细胞用于体外受精。收集所有卵巢并用于生化因子分析。剂量超过10 µg/kg的双酚S暴露会导致植入前胚胎发育停滞。此外，卵巢中的脂质过氧化测量表明，所有剂量的BPS都会导致雌性小鼠氧化应激。总之，即使低剂量施用BPS也会导致小鼠雌性生殖毒性和氧化应激。
