Oh Su Jung, Mandel Philipp, Chun Felix K H, Tennstedt Pierre, Peine Sven, Hohenhorst Jan Lukas, Hiller Jens, Graefen Markus, Tilki Derya, Steuber Thomas
Martini Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Department of Anatomy and Experimental Morphology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Front Surg. 2017 Dec 18;4:75. doi: 10.3389/fsurg.2017.00075. eCollection 2017.
AB0 blood group is an inherited characteristic that has been associated with the incidence as well as the prognosis of several malignancies. The aim of the current study was to clarify the role of the blood group in cancer epidemiology and clinical outcome of patients with prostate cancer (PCa).
Data from 3,574 patients undergoing radical prostatectomy between 2009 and 2010 at a single European institution were retrospectively analyzed. The correlation of AB0 and Rhesus blood group with PCa-related characteristics and oncological outcome were evaluated using univariable and multivariable Cox proportional hazard models.
Median follow-up was 36.9 months. The overall distributions of AB0, as well as Rhesus blood groups among patients with PCa, did not differ from the distribution observed in the normal population. There was no significant association between AB0/Rhesus blood groups and Gleason score, prostate volume, surgical margin, pT-stage, pN-status, or preoperative prostate-specific antigen level. In multivariable Cox regression analysis, no statistically significant correlation between AB0/Rhesus group and biochemical recurrence was observed (all > 0.05).
Our data suggest no relevant association of AB0/Rhesus blood group with adverse clinicopathological tumor characteristics or oncological outcome after surgery in contrast to several other malignancies.
ABO血型是一种遗传特征，与多种恶性肿瘤的发病率及预后相关。本研究旨在阐明血型在前列腺癌（PCa）患者的癌症流行病学及临床结局中的作用。
回顾性分析了2009年至2010年期间在一家欧洲机构接受根治性前列腺切除术的3574例患者的数据。使用单变量和多变量Cox比例风险模型评估ABO和Rh血型与PCa相关特征及肿瘤学结局的相关性。
中位随访时间为36.9个月。PCa患者中ABO及Rh血型的总体分布与正常人群中观察到的分布无差异。ABO/Rh血型与 Gleason评分、前列腺体积、手术切缘、pT分期、pN状态或术前前列腺特异性抗原水平之间无显著关联。在多变量Cox回归分析中，未观察到ABO/Rh血型与生化复发之间存在统计学显著相关性（所有P>0.05）。
与其他几种恶性肿瘤不同，我们的数据表明ABO/Rh血型与不良临床病理肿瘤特征或术后肿瘤学结局无相关性。
