Kaiser Hannah, Kvist-Hansen Amanda, Krakauer Martin, Gørtz Peter Michael, Henningsen Kristoffer Mads Aaris, Wang Xing, Becker Christine, Zachariae Claus, Skov Lone, Hansen Peter Riis
Department of Cardiology, Herlev and Gentofte Hospital, 2900 Hellerup, Denmark.
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, 2900 Hellerup, Denmark.
Life (Basel). 2021 Apr 1;11(4):305. doi: 10.3390/life11040305.
Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) in patients with psoriasis ( = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; < 0.001), SAT (β = 0.28; < 0.001), PAT (β = 0.24; < 0.001), spleen (β = 1.35; = 0.001), and bone marrow (β = 1.14; < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.
银屑病与动脉粥样硬化性心血管疾病（CVD）相关，炎症途径存在显著重叠。血管炎症与多种脂肪组织、脾脏和骨髓中的炎症之间可能存在联系。因此，我们使用F - 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG-PET/CT）对83例银屑病患者进行了这些关联研究，其中一半患者已确诊患有CVD。还进行了颈动脉超声成像。通过分别测量主动脉、内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、心包脂肪组织（PAT）以及脾脏和骨髓中的FDG摄取来评估炎症。血管炎症与所有脂肪组织中的FDG摄取相关，包括VAT（β = 0.26；P < 0.001）、SAT（β = 0.28；P < 0.001）、PAT（β = 0.24；P < 0.001）、脾脏（β = 1.35；P = 0.001）和骨髓（β = 1.14；P < 0.001）。对年龄、性别、体重指数和高敏C反应蛋白进行校正后，结果未改变。这些关联在无既往CVD的患者中通常也存在。未观察到血管炎症与颈动脉内膜中层厚度或颈动脉斑块存在之间的关联。结果表明银屑病患者的血管与脂肪组织、脾脏和骨髓之间存在炎症联系。
