Department of Medical Oncology, Lung Cancer Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Oncol Rep. 2018 Mar;39(3):1414-1422. doi: 10.3892/or.2018.6190. Epub 2018 Jan 4.
Studies have shown that aspirin and metformin play important roles in chemoprevention and repression of breast cancers, even though the exact mechanism remains unclear. Aspirin is capable of stimulating apoptosis through prostaglandin-dependent or prostaglandin-independent pathways. Metformin inhibits cell growth by enhancing the tumor suppressive function of transforming growth factor (TGF-β). In the present study, we report a new link between aspirin, metformin, TGF-β1 and murine breast cancer inhibition. Specifically, we showed that aspirin and metformin enhanced 4T1 cell apoptosis by inducing secretion of TGF-β1, whereas estradiol weakened the effect.
研究表明，阿司匹林和二甲双胍在乳腺癌的化学预防和抑制中发挥着重要作用，尽管其确切机制尚不清楚。阿司匹林能够通过前列腺素依赖或非依赖途径刺激细胞凋亡。二甲双胍通过增强转化生长因子 (TGF-β) 的肿瘤抑制功能来抑制细胞生长。在本研究中，我们报告了阿司匹林、二甲双胍、TGF-β1 和小鼠乳腺癌抑制之间的新联系。具体来说，我们表明阿司匹林和二甲双胍通过诱导 TGF-β1 的分泌来增强 4T1 细胞凋亡，而雌二醇则削弱了这种作用。
