Kanwal Fariha, Ma Mingming, Rehman Muhammad Fayyaz Ur, Khan Fahim-Ullah, Elizur Shai E, Batool Aima Iram, Wang Chi Chiu, Tabassum Tahira, Lu Changrui, Wang Yao
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.
Department of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Front Mol Biosci. 2022 Jan 28;8:788279. doi: 10.3389/fmolb.2021.788279. eCollection 2021.
Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared for targeted breast cancer therapy. The vehicle hinges on MNP altered with polymer polyethylene glycol (PG), polydopamine (PD), and F. The delivery vehicle was studied for drug release, cytotoxicity, and breast cancer cell proliferation. F-conjugated drug delivery vehicles let MNPs achieve an elevated targeting efficacy, ideal for cancer therapy. It was also observed that compared to free aspirin, our drug delivery system (MNP-Asp-PD-PG-F) has a higher cytotoxic and antiproliferative effect on breast cancer cells. The drug delivery system can be proposed as a targeted breast cancer therapy that could be further focused on other targeted cancer therapies. Delivering aspirin by the PD-PG-F system on the tumor sites promises a therapeutic potential for breast cancer treatment.
全球每年有超过100万女性受乳腺癌影响。通过这项研究，我们开发了一种基于纳米颗粒的药物递送系统来靶向乳腺癌细胞。阿司匹林已被发现具有预防肿瘤的活性，可抑制血栓栓塞性疾病。因此，它能缓解疾病症状和严重程度。在此，介孔二氧化硅纳米颗粒（MNPs）已被用于将阿司匹林递送至肿瘤部位。制备了基于MNPs的阿司匹林负载于叶酸（F）共轭聚多巴胺（MNP-Asp-PD-PG-F）载体中，用于靶向乳腺癌治疗。该载体依赖于用聚合物聚乙二醇（PG）、聚多巴胺（PD）和F修饰的MNPs。对该递送载体进行了药物释放、细胞毒性和乳腺癌细胞增殖的研究。F共轭药物递送载体使MNPs具有更高的靶向效率，非常适合癌症治疗。还观察到，与游离阿司匹林相比，我们的药物递送系统（MNP-Asp-PD-PG-F）对乳腺癌细胞具有更高的细胞毒性和抗增殖作用。该药物递送系统可作为一种靶向乳腺癌治疗方法，有望进一步应用于其他靶向癌症治疗。通过PD-PG-F系统在肿瘤部位递送阿司匹林有望为乳腺癌治疗带来治疗潜力。
