Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, 13635-900, São Paulo, Brasil.
Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Odontologia de São José dos Campos, 12245-000, São Paulo, Brasil.
J Biomed Mater Res B Appl Biomater. 2018 Oct;106(7):2615-2624. doi: 10.1002/jbm.b.34078. Epub 2018 Jan 12.
The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al O containing 5% by volume of ZrO were produced by the replica method. These scaffolds had their surfaces chemically treated with phosphoric acid and were coated with calcium phosphate using the biomimetic method simulated body fluid (SBF, 5×) for 14 days. The scaffolds, before and after biomimetic coating, were characterized mechanically, morphologically and structurally by axial compression tests, scanning electron microscopy, microtomography, apparent porosity, X-ray diffractometry, near-infrared spectroscopy, inductively coupled plasma optical emission spectroscopy, energy dispersive X-ray spectroscopy and reactivity. The in vitro cell viability and formation of mineralization nodules were used to identify the potential for bone regeneration. The produced scaffols after immersion in SBF were able to induce the nodules formation. These characteristics are advantaged by the formation of different phases of calcium phosphates on the material surface in a reduced incubation period. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2615-2624, 2018.
经食品和药物管理局批准的生物材料的改性可以作为减少人类使用期限的一种替代方法。多孔生物陶瓷被广泛用作骨形成和修复的支撑结构。这种复合材料具有植入物的基本特性，包括良好的机械性能、高化学稳定性、生物相容性和足够的美观外观。在这里，通过复制法生产了体积分数为 5%的 Al O 中含有 5%ZrO 的三维多孔支架。这些支架的表面用磷酸进行化学处理，并使用仿生模拟体液（SBF，5×）在 14 天内涂覆磷酸钙。对仿生涂层前后的支架进行了机械、形态和结构表征，通过轴向压缩试验、扫描电子显微镜、微断层扫描、表观孔隙率、X 射线衍射、近红外光谱、电感耦合等离子体发射光谱、能量色散 X 射线光谱和反应性。体外细胞活力和矿化结节的形成用于鉴定骨再生的潜力。在 SBF 中浸泡后的生产支架能够诱导结节形成。这些特性得益于在缩短孵育期内在材料表面形成不同的磷酸钙相。©2018 年 Wiley 期刊，生物医学材料研究杂志 B 部分：应用生物材料，106B：2615-2624，2018 年。
