α-氨基酸与β-酮醛的脱羧环化反应。
Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.
机构信息
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.
出版信息
Org Lett. 2018 Feb 2;20(3):602-604. doi: 10.1021/acs.orglett.7b03721. Epub 2018 Jan 12.
Abstract
Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates.
摘要
吲哚里西啶和喹诺里西啶衍生物可通过脱羧环合过程，由 l-脯氨酸或（±）-哌啶酸和β-酮醛轻易地组装而成。这些反应由乙酸促进，并涉及亚甲胺叶立德作为反应中间体。
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