检查淋巴结总数对胰腺神经内分泌肿瘤N分期及生存的预测作用
Predictive Effect of the Total Number of Examined Lymph Nodes on N Staging and Survival in Pancreatic Neuroendocrine Neoplasms.
作者信息
Zhang Xianbin, Lu Lili, Liu Peng, Cao Fei, Wei Yushan, Ma Li, Gong Peng
出版信息
Pancreas. 2018 Feb;47(2):183-189. doi: 10.1097/MPA.0000000000000987.
OBJECTIVES
We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold.
METHODS
A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression and Cox proportional hazards model were used to identify predictive factors associated with N stage and survival, respectively.
RESULTS
Totally, 1280 pNENs were analyzed. The 11 to 15 lymph nodes examined showed a strong association with the N1 stage (6-10 vs 11-15: odds ratio, 0.672; P = 0.042; 11-15 vs 16-20: odds ratio, 1.049; P = 0.840). However, it failed to show any survival benefit in pNENs with or without lymph node metastasis.
CONCLUSIONS
Examining at least 11 lymph nodes may be useful to accurately classify the N stage for pNENs.
目的
我们旨在研究检查的淋巴结总数对胰腺神经内分泌肿瘤（pNENs）N分期及生存的预测作用，并确定最佳阈值。
方法
从监测、流行病学和最终结果数据库中提取2004年至2013年的pNENs数据集。分别使用多因素逻辑回归和Cox比例风险模型来识别与N分期和生存相关的预测因素。
结果
共分析了1280例pNENs。检查11至15个淋巴结与N1期密切相关（6 - 10个与11 - 15个：比值比，0.672；P = 0.042；11 - 15个与16 - 20个：比值比，1.049；P = 0.840）。然而，在有或无淋巴结转移的pNENs中，它未显示出任何生存获益。
结论
检查至少11个淋巴结可能有助于准确对pNENs进行N分期。
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