Department of Life Science, Shimane University Faculty of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan.
Department of Life Science, Shimane University Faculty of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan.
Cell Immunol. 2019 Sep;343:103740. doi: 10.1016/j.cellimm.2017.12.014. Epub 2018 Jan 9.
Interleukin-33 (IL-33) has been identified as a natural ligand of ST2L. IL-33 primarily acts as a key regulator of Th2 responses through binding to ST2L, which is antagonized by soluble ST2 (sST2). The IL-33/ST2L axis is involved in various inflammatory pathologies, including ulcerative colitis (UC). Several recent investigations have also suggested that the IL-33/ST2L axis plays a role in colorectal cancer (CRC) progression. In CRC, tumor- and stroma-derived IL-33 may activate ST2L on various cell types in an autocrine and paracrine manner. Although several findings support the hypothesis that the IL-33/ST2L axis positively regulates CRC progression, other reports do not; hence, this hypothesis remains controversial. At any rate, recent studies have provided overwhelming evidence that the IL-33/ST2L axis plays important roles in CRC progression. This review summarizes the role of the IL-33/ST2L axis in the UC and CRC microenvironments.
白细胞介素 33（IL-33）已被确定为 ST2L 的天然配体。IL-33 主要通过与 ST2L 结合作为 Th2 反应的关键调节剂起作用，而可溶性 ST2（sST2）拮抗其作用。IL-33/ST2L 轴参与各种炎症性病理，包括溃疡性结肠炎（UC）。最近的几项研究还表明，IL-33/ST2L 轴在结直肠癌（CRC）进展中起作用。在 CRC 中，肿瘤和基质来源的 IL-33 可能以自分泌和旁分泌方式激活各种细胞类型上的 ST2L。尽管有几项发现支持 IL-33/ST2L 轴正向调节 CRC 进展的假设，但其他报告则不支持；因此，该假设仍存在争议。无论如何，最近的研究提供了压倒性的证据表明，IL-33/ST2L 轴在 CRC 进展中起重要作用。这篇综述总结了 IL-33/ST2L 轴在 UC 和 CRC 微环境中的作用。
