Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Sci Rep. 2018 Jan 12;8(1):567. doi: 10.1038/s41598-017-16790-8.
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constipation and demographic variables, motor symptoms and other non-motor symptoms of PD are still unknown. PD patients were evaluated by diagnostic criteria of functional constipation in Rome III and divided into PD with constipation (PD-C) and PD with no constipation (PD-NC) groups. PD patients were assessed by rating scales of motor symptoms and other non-motor symptoms, activity of daily living and quality of life. The frequency of constipation in PD patients was 61.4%, and 24.5% of PD patients had constipation before the onset of motor symptoms. PD-C group had older age and age of onset, longer disease duration, more advanced disease stage, and more severe motor symptoms and non-motor symptoms, including worse cognition and emotion, poorer sleep quality, severer autonomic symptoms, fatigue and apathy. Binary Logistic regression analysis showed that the age, H-Y stage, depression, anxiety and autonomic dysfunction increased the risk of constipation in PD patients. Constipation exerted serious impact on the activity of daily living and quality of life in PD patients.
便秘是帕金森病（PD）最常见的非运动症状之一，可能被 PD 患者忽视，导致该问题未能及时报告。便秘与 PD 的人口统计学变量、运动症状和其他非运动症状之间的关系尚不清楚。PD 患者根据罗马 III 功能性便秘的诊断标准进行评估，并分为便秘型 PD（PD-C）和非便秘型 PD（PD-NC）组。PD 患者通过运动症状和其他非运动症状、日常生活活动和生活质量的评分量表进行评估。PD 患者便秘的频率为 61.4%，24.5%的 PD 患者在运动症状出现之前就有便秘。PD-C 组的年龄和发病年龄更大，病程更长，疾病分期更晚，运动症状和非运动症状更严重，包括认知和情绪更差、睡眠质量更差、自主神经症状更严重、疲劳和淡漠。二项 Logistic 回归分析显示，年龄、H-Y 分期、抑郁、焦虑和自主神经功能障碍增加了 PD 患者便秘的风险。便秘对 PD 患者的日常生活活动和生活质量产生了严重影响。
