Di Ningning, Yao Chenjun, Cheng Wenna, Ren Yan, Qu Jianxun, Wang Bin, Yao Zhenwei
Department of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Department of Radiology, Huashan Hospital Fudan University, Shanghai, China.
J Med Imaging Radiat Oncol. 2018 Jan 13. doi: 10.1111/1754-9485.12701.
To ascertain if the volume transfer constant (K ) derived from T1 dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the immunohistological markers of angiogenesis in high-grade gliomas.
Fifty-one image-guided biopsy specimens in 34 patients with newly presenting high-grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE-MRI). We correlated vascular endothelial growth factor (VEGF) expression and the microvessel density (MVD) of MRI-guided biopsy specimens with the corresponding DCE-derived K . Histological sections were stained with VEGF and CD34, and examined under light microscopy. These histological and molecular markers of angiogenesis were correlated with the K of the region of interest corresponding to the biopsy specimen.
The K showed a significant positive correlation with VEGF expression (ρ = 0.582, P = 0.001) but not with MVD stained with CD34 antibody (ρ = 0.328, P = 0.072).
The K derived from DCE-MRI can reflect the VEGF expression of high-grade gliomas but not the MVD.
确定从T1动态对比增强磁共振成像（DCE-MRI）得出的容积转移常数（K）是否与高级别胶质瘤中血管生成的免疫组织学标志物相关。
34例新诊断的高级别胶质瘤患者（III级 = 16例；IV级 = 18例）的51份图像引导活检标本接受了术前成像（传统成像和T1 DCE-MRI）。我们将MRI引导活检标本的血管内皮生长因子（VEGF）表达和微血管密度（MVD）与相应的DCE衍生K进行关联。组织切片用VEGF和CD34染色，并在光学显微镜下检查。这些血管生成的组织学和分子标志物与对应活检标本感兴趣区域的K相关。
K与VEGF表达呈显著正相关（ρ = 0.582，P = 0.001），但与用CD34抗体染色的MVD无相关性（ρ = 0.328，P = 0.072）。
从DCE-MRI得出的K可以反映高级别胶质瘤的VEGF表达，但不能反映MVD。
