高级别胶质瘤中动态对比增强MRI衍生的容积转移常数与组织学血管生成标志物的相关性
Correlation of dynamic contrast-enhanced MRI derived volume transfer constant with histological angiogenic markers in high-grade gliomas.
作者信息
Di Ningning, Yao Chenjun, Cheng Wenna, Ren Yan, Qu Jianxun, Wang Bin, Yao Zhenwei
机构信息
Department of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Department of Radiology, Huashan Hospital Fudan University, Shanghai, China.
出版信息
J Med Imaging Radiat Oncol. 2018 Jan 13. doi: 10.1111/1754-9485.12701.
INTRODUCTION
To ascertain if the volume transfer constant (K ) derived from T1 dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the immunohistological markers of angiogenesis in high-grade gliomas.
METHODS
Fifty-one image-guided biopsy specimens in 34 patients with newly presenting high-grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE-MRI). We correlated vascular endothelial growth factor (VEGF) expression and the microvessel density (MVD) of MRI-guided biopsy specimens with the corresponding DCE-derived K . Histological sections were stained with VEGF and CD34, and examined under light microscopy. These histological and molecular markers of angiogenesis were correlated with the K of the region of interest corresponding to the biopsy specimen.
RESULTS
The K showed a significant positive correlation with VEGF expression (ρ = 0.582, P = 0.001) but not with MVD stained with CD34 antibody (ρ = 0.328, P = 0.072).
CONCLUSION
The K derived from DCE-MRI can reflect the VEGF expression of high-grade gliomas but not the MVD.
引言
确定从T1动态对比增强磁共振成像（DCE-MRI）得出的容积转移常数（K）是否与高级别胶质瘤中血管生成的免疫组织学标志物相关。
方法
34例新诊断的高级别胶质瘤患者（III级 = 16例；IV级 = 18例）的51份图像引导活检标本接受了术前成像（传统成像和T1 DCE-MRI）。我们将MRI引导活检标本的血管内皮生长因子（VEGF）表达和微血管密度（MVD）与相应的DCE衍生K进行关联。组织切片用VEGF和CD34染色，并在光学显微镜下检查。这些血管生成的组织学和分子标志物与对应活检标本感兴趣区域的K相关。
结果
K与VEGF表达呈显著正相关（ρ = 0.582，P = 0.001），但与用CD34抗体染色的MVD无相关性（ρ = 0.328，P = 0.072）。
结论
从DCE-MRI得出的K可以反映高级别胶质瘤的VEGF表达，但不能反映MVD。
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