DCE-MRI 直方图分析参数与包括 EGFR、p16、VEGF、Hif1-α 和 p53 表达在内的头颈部鳞癌组织学特征的相关性研究。
Associations between Histogram Analysis Parameters Derived from DCE-MRI and Histopathological Features including Expression of EGFR, p16, VEGF, Hif1-alpha, and p53 in HNSCC.
机构信息
Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Department of Pathology, University of Leipzig, Leipzig, Germany.
出版信息
Contrast Media Mol Imaging. 2019 Jan 2;2019:5081909. doi: 10.1155/2019/5081909. eCollection 2019.
BACKGROUND
Our purpose was to elucidate possible correlations between histogram parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) with several histopathological features in head and neck squamous cell carcinomas (HNSCC).
METHODS
Thirty patients with primary HNSCC were prospectively acquired. Histogram analysis was derived from the DCE-MRI parameters: , , and . Additionally, in all cases, expression of human papilloma virus (p16) hypoxia-inducible factor-1-alpha (Hif1-alpha), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and tumor suppressor protein p53 were estimated.
RESULTS
kurtosis was significantly higher in p16 tumors, and min was significantly lower in p16 tumors compared to the p16 negative tumors. In the overall sample, entropy correlated well with EGFR expression (=0.38, =0.04). In p16 positive carcinomas, max correlated with VEGF expression (=0.46, =0.04), kurtosis correlated with Hif1-alpha expression (=0.46, =0.04), and entropy correlated with EGFR expression (=0.50, =0.03). Regarding parameters, mode correlated with VEGF expression (=0.51, =0.02), and entropy correlated with Hif1-alpha expression (=0.47, =0.04). In p16 negative carcinomas, mode correlated with Her2 expression (=-0.72, =0.03), max correlated with p53 expression (=-0.80, =0.009), and p10 correlated with EGFR expression (=0.68, =0.04).
CONCLUSION
DCE-MRI can reflect several histopathological features in HNSCC. Associations between DCE-MRI and histopathology in HNSCC depend on p16 status. kurtosis and min can differentiate p16 positive and p16 negative carcinomas.
背景
本研究旨在阐明从动态对比增强磁共振成像（DCE-MRI）获得的直方图参数与头颈部鳞状细胞癌（HNSCC）的几种组织病理学特征之间可能存在的相关性。
方法
前瞻性采集了 30 例原发性 HNSCC 患者。从 DCE-MRI 参数中得出直方图分析：、和。此外，在所有病例中，均估计了人乳头瘤病毒（p16）、缺氧诱导因子-1-α（Hif1-α）、血管内皮生长因子（VEGF）、表皮生长因子受体（EGFR）和肿瘤抑制蛋白 p53 的表达。
结果
与 p16 阴性肿瘤相比，p16 肿瘤的峰度明显更高，而 p16 肿瘤的 min 明显更低。在总体样本中，熵与 EGFR 表达呈良好相关性（=0.38，=0.04）。在 p16 阳性癌中，max 与 VEGF 表达呈相关性（=0.46，=0.04），峰度与 Hif1-α表达呈相关性（=0.46，=0.04），熵与 EGFR 表达呈相关性（=0.50，=0.03）。关于参数，模式与 VEGF 表达呈相关性（=0.51，=0.02），熵与 Hif1-α表达呈相关性（=0.47，=0.04）。在 p16 阴性癌中，模式与 Her2 表达呈相关性（=-0.72，=0.03），max 与 p53 表达呈相关性（=-0.80，=0.009），p10 与 EGFR 表达呈相关性（=0.68，=0.04）。
结论
DCE-MRI 可以反映 HNSCC 的几种组织病理学特征。HNSCC 中 DCE-MRI 与组织病理学之间的相关性取决于 p16 状态。峰度和 min 可以区分 p16 阳性和 p16 阴性癌。
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