Laboratory of Analytical & Molecular Toxicology (Forensic Chemistry and Toxicology laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India.
Pesticide Toxicology Division, National Institute of Occupational Health, Ahmedabad, Gujarat, India.
Environ Toxicol Pharmacol. 2018 Mar;58:141-155. doi: 10.1016/j.etap.2017.12.021. Epub 2017 Dec 27.
Aldrin (ALD), a persistent-organic-pollutant (POP), an organochlorine-cyclodiene-pesticide is highly toxic in nature. Titanium dioxide nanoparticles (TNP) are widely used for various industrial applications. Despite the remarkable research on pesticide toxicity, the work with impact of nanoparticles on POP has been dealt with marginally. Chemicals co-exist in the environment and exhibit interactive effects. An investigation was carried out to evaluate the individual and combined effects of ALD (6 ppm) and TNP (60 ppm) exposure at sub-lethal concentration for 24 h in zebrafish. Significant reversal of lipid peroxidation level in liver and brain tissues and restoration in enhanced catalase activity in all examined tissues were observed in combined group. For other parameters, combined exposure of ALD and TNP does not show significant reversal action on ALD toxicity. Further studies are inline to understand combined effects of both to achieve significant reversal of ALD toxicity by TNP nanoparticles with threshold concentration of aldrin.
aldrin(ALD)，一种持久性有机污染物(POP)，是一种有机氯环二烯类农药，性质剧毒。纳米二氧化钛(TNP)广泛应用于各种工业应用。尽管对农药毒性进行了大量研究，但对纳米颗粒对 POP 的影响的研究却很少涉及。化学物质在环境中共存，并表现出相互作用。本研究旨在评估在亚致死浓度下，单独及联合暴露于 ALD(6ppm)和 TNP(60ppm) 24 小时对斑马鱼的影响。结果显示，联合组的肝脏和脑组织中脂质过氧化水平显著逆转，所有检测组织中的过氧化氢酶活性增强。对于其他参数，ALD 和 TNP 的联合暴露对 ALD 毒性没有显著的逆转作用。进一步的研究旨在了解两者的联合作用，以实现在 aldrin 的阈值浓度下，TNP 纳米粒子对 ALD 毒性的显著逆转。
