School of Chemical Engineering, Nanjing University of Science & Technology , Nanjing 210094, People's Republic of China.
J Org Chem. 2018 Feb 16;83(4):2274-2281. doi: 10.1021/acs.joc.7b03174. Epub 2018 Jan 25.
A CpIr complex bearing a functional bipyridonate ligand [CpIr(2,2'-bpyO)(HO)] was found to be a highly efficient and general catalyst for transfer hydrogenation of aldehydes and chemoselective transfer hydrogenation of unsaturated aldehydes with isopropanol under neutral conditions. It was noteworthy that many readily reducible or labile functional groups such as nitro, cyano, ester, and halide did not undergo any change under the reaction conditions. Furthermore, this catalytic system exhibited high activity for transfer hydrogenation of ketones with isopropanol. Notably, this research exhibited new potential of metal-ligand bifunctional catalysts for transfer hydrogenation.
研究发现，一种带有功能性联吡啶配体[CpIr(2,2'-bpyO)(HO)]的CpIr 配合物是一种高效、通用的催化剂，可在中性条件下，用异丙醇实现醛的转移氢化和不饱和醛的选择性转移氢化。值得注意的是，许多易于还原或不稳定的官能团，如硝基、氰基、酯基和卤化物，在反应条件下都没有发生任何变化。此外，该催化体系对酮的异丙醇转移氢化也表现出很高的活性。值得注意的是，这项研究为转移氢化中的金属-配体双功能催化剂展示了新的潜力。
