Heltberg A, Kalland T, Källén B, Nilsson O
Eur Neurol. 1985;24(6):361-73. doi: 10.1159/000115828.
11 twin pairs, discordant for multiple sclerosis (MS), were studied: 5 were monozygotic, 6 dizygotic. The mixed leukocyte reaction (MLR) with cells from unrelated patients with MS, the natural killer cell (NK) activity, OKT 4/OKT 8 ratio, and monocyte numbers were studied. The impaired MLR seen in some patients with MS was even more pronounced in the healthy twin, irrespective of the zygosity of the twins. A reduced NK activity and a high OKT 4/OKT 8 ratio is seen in the diseased twin compared to the healthy one, more strongly indicated at monozygosity. The significance of genetics, early environment, and disease is discussed.
对11对患多发性硬化症（MS）不一致的双胞胎进行了研究：其中5对为单卵双胞胎，6对为双卵双胞胎。研究了与无关MS患者细胞的混合淋巴细胞反应（MLR）、自然杀伤细胞（NK）活性、OKT 4/OKT 8比值和单核细胞数量。在一些MS患者中观察到的受损MLR在健康双胞胎中更为明显，无论双胞胎的合子性如何。与健康双胞胎相比，患病双胞胎的NK活性降低，OKT 4/OKT 8比值升高，单卵双胞胎的这种情况更为明显。讨论了遗传学、早期环境和疾病的意义。
