New York Obesity Nutrition Research Center, Department of Medicine, Columbia University Medical Center, New York, NY.
Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, Cornell University, New York, NY.
Sleep Health. 2018 Feb;4(1):33-39. doi: 10.1016/j.sleh.2017.10.005. Epub 2017 Nov 20.
This pilot study tested the independent and interactive effects of sleep and meal times, under identical sleep duration and feeding conditions, on insulin sensitivity (Si) in overweight adults. Participants underwent a 4-phase randomized crossover inpatient study differing in sleep times: normal (Ns: 0000-0800 hours) or late (Ls: 0330-1130 hours); and in meal times: normal (Nm: 1, 5, 11, and 12.5 hours after awakening) or late (Lm: 4.5, 8.5, 14.5, and 16 hours after awakening). An insulin-modified frequently sampled intravenous glucose tolerance test, at scheduled breakfast time, and a meal tolerance test, at scheduled lunch time, were performed to assess Si after 3 days in each condition. Six participants were enrolled (4 men, 2 women; mean age 25.1±[SD] 3.9 years, body mass index 29.2±2.7 kg/m); only 1 failed to complete her last study phase. There were no effects of sleep and meal times or sleep × meal time interaction on Si (all P>.35), acute insulin response to intravenous glucose (all P>.20), and disposition index (all P>.60) after adjusting for sex and body mass index. Meal tolerance test glucose and insulin areas under the curve were lower during Nm (glucose P=.11; insulin P=.0088). There were a sleep × meal interaction and an effect of meal times on overnight glucose (P=.0040 and .012, respectively) and insulin (P=.0075 and .067, respectively). Sleep timing, without concomitant sleep restriction, does not adversely affect Si and glucose tolerance, but meal times may be relevant for health. Our results should be confirmed in a larger sample.
这项初步研究测试了在相同的睡眠时长和喂养条件下，睡眠和用餐时间对超重成年人胰岛素敏感性（Si）的独立和交互影响。参与者接受了为期 4 期的随机交叉住院研究，其中睡眠时间不同：正常（Ns：0000-0800 小时）或晚（Ls：0330-1130 小时）；用餐时间不同：正常（Nm：觉醒后 1、5、11 和 12.5 小时）或晚（Lm：觉醒后 4.5、8.5、14.5 和 16 小时）。在每种情况下进行 3 天后，在预定的早餐时间进行胰岛素改良的频繁采样静脉葡萄糖耐量试验和在预定的午餐时间进行餐耐受性试验，以评估 Si。纳入了 6 名参与者（4 名男性，2 名女性；平均年龄 25.1±[标准差]3.9 岁，体重指数 29.2±2.7kg/m²；只有 1 人未能完成她的最后一个研究阶段）。调整性别和体重指数后，睡眠和用餐时间或睡眠×用餐时间交互作用对 Si（所有 P>.35）、静脉葡萄糖急性胰岛素反应（所有 P>.20）和处置指数（所有 P>.60）均无影响。在 Nm 时，餐耐受性试验的血糖和胰岛素曲线下面积较低（血糖 P=.11；胰岛素 P=.0088）。存在睡眠×用餐时间交互作用和用餐时间对 overnight glucose（P=.0040 和.012，分别）和 insulin（P=.0075 和.067，分别）的影响。在不伴有睡眠限制的情况下，睡眠时间不会对 Si 和葡萄糖耐量产生不利影响，但用餐时间可能与健康有关。我们的结果应在更大的样本中得到证实。
