α-人心房利钠多肽（α-hANP）对自发性高血压大鼠的心脏抑制作用。
Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive rats.
作者信息
Sasaki A, Kida O, Kangawa K, Matsuo H, Tanaka K
出版信息
Eur J Pharmacol. 1985 Sep 24;115(2-3):321-4. doi: 10.1016/0014-2999(85)90709-5.
The hemodynamic effects of alpha-hANP were investigated in anesthetized WKY and SHR. Intravenous administration of alpha-hANP (30 ng/min per 100 g bw) caused a marked and rapid reduction in mean blood pressure (MBP) and cardiac index (CI) without any change in the total peripheral resistance index in both strains of rat. The reduction in MBP and CI was significantly greater in SHR than in WKY. It is suggested that SHR may have an enhanced cardiovascular response to alpha-hANP, but the detailed mechanism of such a response is not known.
在麻醉的WKY大鼠和SHR大鼠中研究了α-hANP的血流动力学效应。静脉注射α-hANP（每100 g体重30 ng/min）导致两种品系大鼠的平均血压（MBP）和心脏指数（CI）显著快速降低，而总外周阻力指数无任何变化。SHR大鼠中MBP和CI的降低显著大于WKY大鼠。提示SHR大鼠可能对α-hANP有增强的心血管反应，但这种反应的详细机制尚不清楚。
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