Duffy L F, Daum F, Kahn E, Teichberg S, Pahwa R, Fagin J, Kenigsberg K, Kaplan M, Fisher S E, Pahwa S
Gastroenterology. 1986 Jan;90(1):173-81. doi: 10.1016/0016-5085(86)90090-9.
Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both lobular and portal changes were noted. Lymphocytic infiltration, piecemeal necrosis, hepatocellular and bile duct damage, sinusoidal cell hyperplasia, and endothelialitis were prominent. Vesicular rosettes in sinusoidal lymphocytes and tubuloreticular structures in sinusoidal endothelial cells were demonstrated by electron microscopy. The lymphocytic infiltrate in both the lobular and portal spaces was characterized by a relative increase of cytotoxic/suppressor (T8) cells. Hepatitis may be a common feature of pediatric acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex. Although the histopathologic changes are consistent with chronic active hepatitis, the specific pathogenesis remains to be determined.
对4名具有获得性免疫缺陷综合征或与获得性免疫缺陷综合征相关综合征临床和免疫学特征的儿童进行了肝脏形态学和免疫细胞学评估。所有4名儿童均有肝肿大，血清丙氨酸和天冬氨酸转氨酶活性升高。观察到小叶和门脉区均有改变。淋巴细胞浸润、碎片状坏死、肝细胞和胆管损伤、窦状隙细胞增生以及内皮细胞炎较为突出。电镜显示窦状隙淋巴细胞中有泡状玫瑰花结，窦状隙内皮细胞中有管状网状结构。小叶和门脉区的淋巴细胞浸润均以细胞毒性/抑制性（T8）细胞相对增多为特征。肝炎可能是儿童获得性免疫缺陷综合征和与获得性免疫缺陷综合征相关综合征的常见特征。虽然组织病理学改变与慢性活动性肝炎一致，但具体发病机制仍有待确定。
