Wertheim D L, Valderamma E, Bonagura V R
Division of Allergy and Immunology, Schneider Children's Hospital, New Hyde Park, New York 11042, USA.
Clin Diagn Lab Immunol. 1994 May;1(3):361-3. doi: 10.1128/cdli.1.3.361-363.1994.
Hepatitis is a common complication of human immunodeficiency virus (HIV) disease in children. Often a distinct pathogen cannot be identified. Therefore, by exclusion, one must consider HIV the direct pathogen. Zidovudine (AZT) has not been used as a treatment for HIV-positive children with presumed HIV-induced hepatitis because of the potential of this medication to exacerbate preexisting hepatitis. We have used AZT to treat an 8-month-old female with severe HIV-induced hepatitis and have achieved complete remission with this regimen. For some HIV-positive children with HIV-induced hepatitis, AZT may be the drug of choice to resolve hepatic inflammation caused by this virus.
肝炎是儿童人类免疫缺陷病毒（HIV）疾病的常见并发症。通常无法确定具体的病原体。因此，通过排除法，必须将HIV视为直接病原体。由于齐多夫定（AZT）有加重原有肝炎的可能性，所以尚未用于治疗疑似HIV诱发肝炎的HIV阳性儿童。我们使用AZT治疗一名患有严重HIV诱发肝炎的8个月大女性，并通过该方案实现了完全缓解。对于一些患有HIV诱发肝炎的HIV阳性儿童，AZT可能是解决该病毒引起的肝脏炎症的首选药物。
