Byrne Raphael M, Tsikitis Vassiliki Liana
Department of Surgery, Division of GI and General Surgery, Oregon Health & Science University, Portland, OR, USA.
Ann Gastroenterol. 2018 Jan-Feb;31(1):24-34. doi: 10.20524/aog.2017.0218. Epub 2017 Nov 27.
The majority of colorectal cancer (CRC) cases are sporadic, with hereditary factors contributing to approximately 35% of CRC cases. Less than 5% of CRC is associated with a known genetic syndrome. Although adenomatous polyposis syndromes, hamartomatous polyposis syndromes, and those previously classified as non-polyposis CRC syndromes are quite rare, it is important for clinicians to know the characteristics of each syndrome and to understand the differences in cancer risks between the different conditions. This information is very important when treatment and surveillance plans are formulated for each individual patient.
大多数结直肠癌（CRC）病例是散发性的，遗传因素导致约35%的CRC病例。不到5%的CRC与已知的遗传综合征相关。尽管腺瘤性息肉病综合征、错构瘤性息肉病综合征以及那些以前归类为非息肉病性CRC综合征的情况相当罕见，但临床医生了解每种综合征的特征并理解不同情况之间癌症风险的差异很重要。在为每个患者制定治疗和监测计划时，这些信息非常重要。
