毛细血管扩张性骨肉瘤的超微结构
Ultrastructure of telangiectatic osteosarcoma.
作者信息
Roessner A, Hobik H P, Immenkamp M, Grundmann E
出版信息
J Cancer Res Clin Oncol. 1979 Oct;95(2):197-207. doi: 10.1007/BF00401013.
Recent investigations have shown that telangiectatic osteosarcoma has a poorer prognosis than other osteosarcomas. To elucidate the histogenesis of TOS two cases were investigated on the electron microscopic level. The results show that besides anaplastic, osteoblast-like, and fibroblast-like tumor cells angiosarcomatous components can be observed in this malignant bone tumor, which are characterized by endothelial cells with pinocytotic vesicles, tight intercellular junctions, fine fibrils, and so-called Weibel-Palade bodies in their cytoplasm. From these results, it is concluded that telangiectatic osteosarcoma is derived from multipotent mesenchymal cells with potential differentiation into various directions, such as osteoblast-like cells, and fibroblast-like cells.
近期研究表明，毛细血管扩张性骨肉瘤的预后比其他骨肉瘤更差。为阐明毛细血管扩张性骨肉瘤（TOS）的组织发生，对两例病例进行了电子显微镜水平的研究。结果显示，在这种恶性骨肿瘤中，除了间变的、成骨细胞样和成纤维细胞样肿瘤细胞外，还可观察到血管肉瘤成分，其特征为内皮细胞含有吞饮小泡、紧密的细胞间连接、细纤维，且细胞质中有所谓的魏-帕小体。从这些结果得出结论，毛细血管扩张性骨肉瘤起源于具有向成骨细胞样细胞和成纤维细胞样细胞等多种方向分化潜能的多能间充质细胞。
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