Kim Sulhee, Chang Hyeyoon, Hwang Jin Wook, Kim Sungtae, Koo Ki-Tae, Kim Tae-Il, Seol Yang-Jo, Lee Yong-Moo, Ku Young, Lee Jong-Ho, Rhyu In-Chul
Department of Periodontology, Seoul National University School of Dentistry, Seoul, Korea.
ESTeam Paris Sud, INSERM UMR-S 935, Paris-Sud University, Paris-Saclay University, Villejuif, France.
J Periodontal Implant Sci. 2017 Dec;47(6):363-371. doi: 10.5051/jpis.2017.47.6.363. Epub 2017 Dec 31.
The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically.
Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants. A novel extracellular matrix membrane (NEM) and a widely-used membrane (WEM) were randomly applied to the test group and the control group, respectively. Cone-beam computed tomography images were obtained on the day of surgery and 6 months after the procedure. Alginate impressions were taken and plaster models were made 1 week and 6 months postoperatively.
The quantity of bone tissue, the dimensional changes of the surgically treated intrabony defects, and the changes in width and height below the grafted bone substitutes showed no significant difference between the test and control groups at the 6-month examination.
The use of NEM for periodontal regeneration with a collagenated bovine bone graft showed similar clinical and radiologic results to those obtained using WEM.
本研究旨在探讨胶原骨移植和可吸收膜用于骨内缺损再生治疗的可行性，并从临床和影像学角度评估新型细胞外基质（ECM）基膜的效果。
在牙齿和种植体周围的骨内缺损处，使用基于ECM的可吸收膜联合胶原牛骨移植进行牙周组织再生手术。将新型细胞外基质膜（NEM）和广泛使用的膜（WEM）分别随机应用于试验组和对照组。在手术当天和术后6个月获取锥形束计算机断层扫描图像。术后1周和6个月制取藻酸盐印模并制作石膏模型。
在6个月的检查中，试验组和对照组在骨组织量、手术治疗的骨内缺损尺寸变化以及移植骨替代物下方的宽度和高度变化方面均无显著差异。
使用NEM联合胶原牛骨移植进行牙周再生，其临床和影像学结果与使用WEM相似。
