前额部不可切除的皮肤鳞状细胞癌，伴有突变，对程序性细胞死亡蛋白1抑制剂治疗表现出显著反应。
Unresectable cutaneous squamous cell carcinoma of the forehead with mutation showing dramatic response to Programmed Cell Death Protein 1 Inhibitor Therapy.
作者信息
Assam Jed H, Powell Steven, Spanos William C
机构信息
Department of Surgery, University of South Dakota Sanford School of Medicine 1400 W 22 St., Sioux Falls, SD 57105, United States.
Department of Internal Medicine, University of South Dakota Sanford School of Medicine, 1400 W 22 St., Sioux Falls, SD 57105, United States.
出版信息
Clin Skin Cancer. 2016 Jan;1(1):26-29. doi: 10.1016/j.clsc.2016.11.001. Epub 2016 Nov 23.
Abstract
Treatment of refractory, unresectable cutaneous squamous cell carcinoma presents a great challenge in head and neck oncology with poor prognosis. Prior case reports have shown off-label pembrolizumab, a programed cell death receptor antagonist, can be effective in unresectable cutaneous squamous cell carcinoma. Furthermore, prior reports have suggested enhanced efficacy when high mutational burden is present. In this study we present a severe case of unresectable cutaneous squamous cell carcinoma invading the orbit and cavernous sinus with documented tumor mutation. The patient had a complete response to palliative, off-label pembrolizumab therapy.
摘要
难治性、不可切除的皮肤鳞状细胞癌的治疗在头颈部肿瘤学中是一项巨大挑战，预后较差。先前的病例报告显示，程序性细胞死亡受体拮抗剂帕博利珠单抗用于非适应证时，对不可切除的皮肤鳞状细胞癌可能有效。此外，先前的报告表明，当存在高肿瘤突变负荷时疗效会增强。在本研究中，我们报告了1例严重的不可切除皮肤鳞状细胞癌侵犯眼眶和海绵窦且有肿瘤突变记录的病例。该患者接受姑息性、非适应证帕博利珠单抗治疗后获得完全缓解。
相似文献
1
Unresectable cutaneous squamous cell carcinoma of the forehead with mutation showing dramatic response to Programmed Cell Death Protein 1 Inhibitor Therapy.前额部不可切除的皮肤鳞状细胞癌，伴有突变，对程序性细胞死亡蛋白1抑制剂治疗表现出显著反应。
Clin Skin Cancer. 2016 Jan;1(1):26-29. doi: 10.1016/j.clsc.2016.11.001. Epub 2016 Nov 23.
2
Complete Resolution of a Large, Locally-advanced Cutaneous Squamous Cell Carcinoma with the Immune-modulating PD-1 Inhibitor Pembrolizumab.使用免疫调节性PD - 1抑制剂帕博利珠单抗使一例大型局部晚期皮肤鳞状细胞癌完全消退
Cureus. 2020 May 12;12(5):e8072. doi: 10.7759/cureus.8072.
3
Dramatic response of refractory metastatic squamous cell carcinoma of the skin with cetuximab/pembrolizumab.西妥昔单抗/帕博利珠单抗治疗难治性转移性皮肤鳞状细胞癌的显著疗效
Ther Adv Med Oncol. 2021 May 31;13:17588359211015493. doi: 10.1177/17588359211015493. eCollection 2021.
4
Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy.多发性角质形成细胞肉芽肿：皮肤鳞状细胞癌对程序性细胞死亡蛋白1抑制剂治疗有反应的潜在组织学线索。
J Cutan Pathol. 2019 Jun;46(6):452-454. doi: 10.1111/cup.13447. Epub 2019 Apr 4.
5
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.帕博利珠单抗治疗头颈部复发或转移性鳞状细胞癌的安全性和临床活性（KEYNOTE-012）：一项开放标签、多中心、1b 期试验。
Lancet Oncol. 2016 Jul;17(7):956-965. doi: 10.1016/S1470-2045(16)30066-3. Epub 2016 May 27.
6
Pembrolizumab and concurrent hypo-fractionated radiotherapy for advanced non-resectable cutaneous squamous cell carcinoma.帕博丽珠单抗联合低分割放射治疗晚期不可切除皮肤鳞状细胞癌。
Eur J Dermatol. 2019 Dec 1;29(6):636-640. doi: 10.1684/ejd.2019.3671.
7
Paraneoplastic Pemphigus Revealed by Anti-programmed Death-1 Pembrolizumab Therapy for Cutaneous Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa.抗程序性死亡-1派姆单抗治疗并发化脓性汗腺炎的皮肤鳞状细胞癌引发的副肿瘤性天疱疮
Front Med (Lausanne). 2019 Nov 5;6:249. doi: 10.3389/fmed.2019.00249. eCollection 2019.
8
A Case Report of Unresectable Cutaneous Squamous Cell Carcinoma Responsive to Pembrolizumab, a Programmed Cell Death Protein 1 Inhibitor.一例对程序性细胞死亡蛋白1抑制剂帕博利珠单抗敏感的不可切除皮肤鳞状细胞癌病例报告
JAMA Dermatol. 2016 Jan;152(1):106-8. doi: 10.1001/jamadermatol.2015.2705.
9
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab.纳武单抗和伊匹单抗成功治疗头颈部难治性鳞状细胞癌
Case Rep Oncol. 2018 Jan 4;11(1):17-20. doi: 10.1159/000485562. eCollection 2018 Jan-Apr.
10
Pembrolizumab for cutaneous squamous cell carcinoma: Report of a case of inoperable squamous cell carcinoma with complete response to pembrolizumab complicated by granulomatous inflammation.帕博利珠单抗治疗皮肤鳞状细胞癌：1例不可切除鳞状细胞癌对帕博利珠单抗完全缓解并并发肉芽肿性炎症的病例报告。
JAAD Case Rep. 2019 May 25;5(6):491-494. doi: 10.1016/j.jdcr.2019.04.006. eCollection 2019 Jun.
引用本文的文献
1
Mutational Profile of Blood and Tumor Tissue and Biomarkers of Response to PD-1 Inhibitors in Patients with Cutaneous Squamous Cell Carcinoma.皮肤鳞状细胞癌患者血液和肿瘤组织的突变谱及对PD-1抑制剂反应的生物标志物
Cancers (Basel). 2025 Mar 31;17(7):1172. doi: 10.3390/cancers17071172.
2
Unresectable squamous cell carcinoma in a patient with spina bifida.脊髓裂患者的不可切除鳞状细胞癌。
BMJ Case Rep. 2024 Sep 28;17(9):e259682. doi: 10.1136/bcr-2024-259682.
3
Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort.与 Lynch 综合征个体皮肤肿瘤相关的临床因素的纵向观察队列研究。
J Am Acad Dermatol. 2023 Jun;88(6):1282-1290. doi: 10.1016/j.jaad.2023.01.035. Epub 2023 Feb 9.
4
Identifying Candidates for Immunotherapy among Patients with Non-Melanoma Skin Cancer: A Review of the Potential Predictors of Response.非黑色素瘤皮肤癌患者中免疫治疗候选者的识别：反应潜在预测因素综述
J Clin Med. 2022 Jun 11;11(12):3364. doi: 10.3390/jcm11123364.
5
Immune Checkpoint Inhibition in Non-Melanoma Skin Cancer: A Review of Current Evidence.非黑色素瘤皮肤癌中的免疫检查点抑制：当前证据综述
Front Oncol. 2021 Dec 20;11:734354. doi: 10.3389/fonc.2021.734354. eCollection 2021.
6
Metachronous cutaneous squamous cell carcinoma in a young patient as the only presenting symptom to uncover Lynch syndrome with MLH1 Germline mutation.一名年轻患者出现异时性皮肤鳞状细胞癌，作为揭示携带MLH1种系突变的林奇综合征的唯一症状。
Hered Cancer Clin Pract. 2020 Nov 16;18(1):23. doi: 10.1186/s13053-020-00155-w.
7
Immune Checkpoint Blockade in Advanced Cutaneous Squamous Cell Carcinoma: What Do We Currently Know in 2020?免疫检查点阻断在晚期皮肤鳞状细胞癌中的应用：2020 年我们对此了解多少？
Int J Mol Sci. 2020 Dec 6;21(23):9300. doi: 10.3390/ijms21239300.
8
PD-1 inhibition therapy for advanced cutaneous squamous cell carcinoma: a retrospective analysis from the University of Southern California.PD-1 抑制疗法治疗晚期皮肤鳞状细胞癌：来自南加州大学的回顾性分析。
J Cancer Res Clin Oncol. 2021 Jun;147(6):1803-1811. doi: 10.1007/s00432-020-03458-6. Epub 2020 Nov 18.
9
Immune checkpoint inhibitors to treat cutaneous malignancies.免疫检查点抑制剂治疗皮肤恶性肿瘤。
J Am Acad Dermatol. 2020 Nov;83(5):1239-1253. doi: 10.1016/j.jaad.2020.03.131. Epub 2020 May 24.
10
The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.抗 PD-1/PD-L1 在皮肤癌治疗中的作用。
BioDrugs. 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9.
本文引用的文献
1
2
Rescue therapy with anti-programmed cell death protein 1 inhibitors of advanced cutaneous squamous cell carcinoma and basosquamous carcinoma: preliminary experience in five cases.抗程序性细胞死亡蛋白1抑制剂用于晚期皮肤鳞状细胞癌和基底鳞状细胞癌的挽救治疗：5例初步经验
Br J Dermatol. 2016 Dec;175(6):1382-1386. doi: 10.1111/bjd.14642. Epub 2016 Oct 17.
3
A Case Report of Unresectable Cutaneous Squamous Cell Carcinoma Responsive to Pembrolizumab, a Programmed Cell Death Protein 1 Inhibitor.一例对程序性细胞死亡蛋白1抑制剂帕博利珠单抗敏感的不可切除皮肤鳞状细胞癌病例报告
JAMA Dermatol. 2016 Jan;152(1):106-8. doi: 10.1001/jamadermatol.2015.2705.
4
New developments in the management of advanced melanoma - role of pembrolizumab.晚期黑色素瘤治疗的新进展——帕博利珠单抗的作用
Onco Targets Ther. 2015 Sep 14;8:2535-43. doi: 10.2147/OTT.S72823. eCollection 2015.
5
Pembrolizumab.帕博利珠单抗。
J Immunother Cancer. 2015 Aug 18;3:36. doi: 10.1186/s40425-015-0078-9. eCollection 2015.
6
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.错配修复缺陷肿瘤中的程序性死亡受体-1阻断
N Engl J Med. 2015 Jun 25;372(26):2509-20. doi: 10.1056/NEJMoa1500596. Epub 2015 May 30.
7
Efficacy of neoadjuvant cetuximab alone or with platinum salt for the treatment of unresectable advanced nonmetastatic cutaneous squamous cell carcinomas.新辅助西妥昔单抗单药或联合铂盐治疗不可切除的晚期非转移性皮肤鳞状细胞癌的疗效。
Br J Dermatol. 2015 Aug;173(2):527-34. doi: 10.1111/bjd.13741. Epub 2015 Aug 8.
8
Mutational landscape of aggressive cutaneous squamous cell carcinoma.侵袭性皮肤鳞状细胞癌的突变图谱
Clin Cancer Res. 2014 Dec 15;20(24):6582-92. doi: 10.1158/1078-0432.CCR-14-1768. Epub 2014 Oct 10.
9
Systemic Therapy in Advanced Cutaneous Squamous Cell Carcinoma (CSCC): The Roswell Park Experience and a Review of the Literature.晚期皮肤鳞状细胞癌（CSCC）的全身治疗：罗斯威尔公园癌症中心的经验及文献综述
Am J Clin Oncol. 2016 Dec;39(6):545-548. doi: 10.1097/COC.0000000000000088.
10
Therapy of advanced squamous cell carcinoma of the skin.晚期皮肤鳞状细胞癌的治疗。
Curr Treat Options Oncol. 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x.
Zotero 插件