Janeczko Monika, Kazimierczuk Zygmunt, Orzeszko Andrzej, Niewiadomy Andrzej, Król Ewa, Szyszka Ryszard, Masłyk Maciej
Department of Molecular Biology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, Lublin, Poland.
Institute of Chemistry, Warsaw University of Life Sciences, Warsaw, Poland.
Pol J Microbiol. 2016 Aug 26;65(3):359-364. doi: 10.5604/17331331.1215615.
A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidazol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi. For this study three plant pathogens Colletotrichum sp., Fusarium sp., and Sclerotinia sp., as well as Staphylococcus sp., Enterococcus sp., Escherichia sp., Enterobacter sp., Klebsiella spp. , and Candida spp. as human pathogens were used. MIC values and/or area of growth reduction method were applied in order to compare the activity of the synthesized compounds. From the presented set of 22 compounds, only 8, 16, 18 and 19 showed moderate to good inhibition against bacterial strains. Against Candida strains only compound 19 with three hydroxyl substituted benzene moiety presented high inhibition at nystatin level or lower.
对一系列广泛的4,5,6,7-四卤代苯并咪唑和4-(1H-苯并咪唑-2-基)-苯-1,3-二醇衍生物针对选定的细菌和真菌进行了测试。在本研究中，使用了三种植物病原体炭疽菌属、镰刀菌属和核盘菌属，以及作为人类病原体的葡萄球菌属、肠球菌属、大肠杆菌属、肠杆菌属、克雷伯菌属和念珠菌属。应用最小抑菌浓度（MIC）值和/或生长减少面积法来比较合成化合物的活性。在所展示的22种化合物中，只有8、16、18和19对细菌菌株表现出中度至良好的抑制作用。针对念珠菌菌株，只有具有三个羟基取代苯部分的化合物19在制霉菌素水平或更低水平表现出高抑制作用。
